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Author Topic: ALZHEIMERS - BRAIN HEALTH posts  (Read 22471 times)


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« Reply #90 on: June 20, 2019, 10:34:49 AM »
What a beautiful tree Barb - I wonder how far north they grow?

Hi R.R. amazingly enough this article says they have been grown as far north as Maryland!! I bet they needed a greenhouse to nurture them for the first few years?

Latitudes at the 0 degree latitudinal mark (right around the equator) grow the healthiest avocados. However, avocado trees can grow between the latitudes of 30 degrees north to 35 degrees south—as far north as Maryland and as far south as South Africa and Australia.
Avocado Tree Zones | Hunker

R.R. Book

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« Reply #91 on: June 20, 2019, 04:23:11 PM »
I'm right around 40 degrees North, so would be one or two planting zones too cold for them here. 

That's too bad for us, but lucky for everyone south of here  :)


  • Guest
« Reply #92 on: June 20, 2019, 10:10:56 PM »
I'm right around 40 degrees North, so would be one or two planting zones too cold for them here. 

That's too bad for us, but lucky for everyone south of here  :)

I hear ya.
Well maybe start a small tree or ten in a greenhouse who knows what climate we might end up with. :)


  • Guest
« Reply #93 on: June 20, 2019, 10:14:11 PM »
Boost Brain Health with Avocados

As a monounsaturated fat, the avocado can lower blood pressure and increase blood flow — two factors that can reduce a person's risk for cognitive decline. ...
High in folate, avocados are thought to prevent the formation of brain tangles thought to cause Alzheimer's.
Oct 20, 2014

10 Avocado Recipes for Brain Health -


  • Guest
« Reply #94 on: December 07, 2019, 06:55:02 PM »
This new Topic whill be a place for Alzheimers and brain health posts.

I just ran across a video, still watching...posting it...
I had mentioned in a post earlier tonight about wanting to start a new topic:  MEMORY.  But I re-discovered this "ALZHEIMERS  -- BRAIN HEALTH posts" and realized this is "THE PLACE"!   More details to follow...


  • Guest
« Reply #95 on: December 08, 2019, 12:23:05 PM »
I had planned to do more organized postings here, but just saw this one today, so here goes.

In addition to helping blood pressure and cardiovascular health, deep sleep may play a role in preventing Alzheimer’s disease

Published: Dec 8, 2019 7:06 a.m. ET

A new study in the peer-reviewed journal Science says cerebrospinal fluid during non–rapid eye movement sleep clears metabolic waste products from the brain


An increasingly large body of evidence demonstrates that sleep disturbance increases the risk of Alzheimer’s disease.

Personal Finance Editor

Deep sleep may be critical for your heart — but it may also help clear the brain of toxins that play a role in Alzheimher’s disease. Sleep is essential for both cognition and maintenance of healthy brain function, and slow waves in neural activity contribute to memory consolidation, a study published Thursday in the peer-reviewed journal Science concluded. Cerebrospinal fluid during non–rapid eye movement sleep also clears metabolic waste products from the brain.

An increasingly large body of evidence demonstrates that sleep disturbance increases the risk of Alzheimer’s disease, a 2018 review of research in the medical journal JAMA concluded. One such study concluded that individuals with sleep problems had a 1.68 times higher risk for developing cognitive impairment or Alzheimer’s disease and that 15% of Alzheimer’s disease cases may be directly attributable to sleep dysfunction.

Staying mentally and physically active also appears to play a role in preventing cognitive impairment. People age 66 and older who got a hearing aid shortly after being diagnosed with hearing loss were less likely to receive a first-time diagnosis of dementia or depression, or be injured by a fall, in the following three years, a study published recently by the Journal of the American Geriatrics Society and carried out by researchers from the University of Michigan found.

A bad night’s sleep can also result in a spike in blood pressure that night and the following day, according to recent research. The study, published in a recent edition of the peer-reviewed scientific journal Psychosomatic Medicine and led by scientists at the University of Arizona, offers one possible explanation for why sleep problems have been shown to increase the risk of heart attack, stroke and even death from cardiovascular disease.

Those participants who had lower “sleep efficiency” showed an increase in blood pressure during that restless night. They also had higher systolic blood pressure — the number in a person’s blood pressure reading — the next day. The researchers said getting a good night’s sleep is important for good long-term health, but so is getting quality sleep, and recommended keeping your smartphone in another room, and pulling down the shades if your bedroom faces east.

“Patients with sleep apnea often have compromised heart health,” according to the National Sleep Foundation. “This is because without long, deep periods of rest, certain chemicals are activated that keep the body from achieving extended periods in which heart rate and blood pressure are lowered.” This 2008 study in the Journal of Clinical Sleep Medicine concluded that individuals with severe sleep apnea are at increased risk for coronary artery disease, congestive heart failure, and stroke.


  • Guest
« Reply #96 on: December 09, 2019, 10:40:50 AM »
(Editor's Note:  It's interesting that after only three months of treatment, beneficial changes were notes in one study....)

Turmeric Produces 'Remarkable' Recovery in Alzheimer's Patients

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Turmeric has been used in India for over 5,000 years, which is likely why still today both rural and urban populations have some of the lowest prevalence rates of Alzheimer's disease (AD) in the world. A study on patients with AD found that less than a gram of turmeric daily, taken for three months, resulted in 'remarkable improvements'
Alzheimer's Disease: A Disturbingly Common Modern Rite of Passage
A diagnosis of Alzheimer's disease (AD), sadly, has become a rite of passage in so-called developed countries. AD is considered the most common form of dementia, which is defined as a serious loss of cognitive function in previously unimpaired persons, beyond what is expected from normal aging.
A 2006 study estimated that 26 million people throughout the world suffer from this condition, and that by 2050, the prevalence will quadruple, by which time 1 in 85 persons worldwide will be afflicted with the disease.[1]
Given the global extent of the problem, interest in safe and effective preventive and therapeutic interventions within the conventional medical and alternative professions alike are growing.
Unfortunately, conventional drug-based approaches amount to declaring chemical war upon the problem, a mistake which we have documented elsewhere, and which can result in serious neurological harm, as evidenced by the fact that this drug class carries an alarmingly high risk for seizures, according to World Health Organization post-marketing surveillance statistics.[2]
What the general public is therefore growing most responsive to is using time-tested, safe, natural and otherwise more effective therapies that rely on foods, spices and familiar culinary ingredients.
Remarkable Recoveries Reported after Administration of Turmeric
Late last year, a remarkable study was published in the journal Ayu titiled "Effects of turmeric on Alzheimer's disease with behavioral and psychological symptoms of dementia." [ii] Researchers described three patients with Alzheimer's disease whose behavioral symptoms were "improved remarkably" as a result of consuming 764 milligram of turmeric (curcumin 100 mg/day) for 12 weeks. According to the study:
All three patients exhibited irritability, agitation, anxiety, and apathy, two patients suffer from urinary incontinence and wonderings. They were prescribed turmeric powder capsules and started recovering from these symptoms without any adverse reaction in the clinical symptom and laboratory data."
After only 3 months of treatment, both the patients' symptoms and the burden on their caregivers were significantly decreased.
The report describes the improvements thusly:
In one case, the Mini-Mental State Examination (MMSE) score was up five points, from 12/30 to 17/30. In the other two cases, no significant change was seen in the MMSE; however, they came to recognize their family within 1 year treatment. All cases have been taking turmeric for more than 1 year, re-exacerbation of BPSD was not seen."
This study illustrates just how powerful a simple natural intervention using a time-tested culinary herb can be. Given that turmeric has been used medicinally and as a culinary ingredient for over 5,000 years in Indian culture, even attaining the status of a 'Golden Goddess,' we should not be surprised at this result. Indeed, epidemiological studies of Indian populations reveal that they have a remarkably lower prevalence of Alzheimer's disease relative to Western nations, [3] and this is true for both rural and more "Westernized" urban areas of India.[4]
Could turmeric be a major reason for this?
Turmeric's Anti-Alzheimer's Properties
The database now contains a broad range of published studies on the value of turmeric, and its primary polyphenol curcumin (which gives it its golden hue), for Alzheimer's disease prevention and treatment.*
While there are 114 studies on our Turmeric research page indicating turmeric has a neuroprotective set of physiological actions, [5] 30 of these studies are directly connected to turmeric's anti-Alzheimer's disease properties.**
Two of these studies are particularly promising, as they reveal that curcumin is capable of enhancing the clearance of the pathological amyloid–beta plaque in Alzheimer's disease patients,[6] and that in combination with vitamin D3 the neurorestorative process is further enhanced.[7] Additional preclinical research indicates curcumin (and its analogs) has inhibitory and protective effects against Alzheimer's disease associated β-amyloid proteins.[8] [9] [10]
Other documented Anti-Alzheimer's mechanisms include:
   •   Anti-inflammatory: Curcumin has been found to play a protective role against β-amyloid protein associated inflammation.[11]
   •   Anti-oxidative: Curcumin may reduce damage via antioxidant properties.[12]
   •   Anti-cytotoxic: Curcumin appears to protect against the cell-damaging effects of β-amyloid proteins.[13] [14]
   •   Anti-amyloidogenic: Turmeric contains a variety of compounds (curcumin, tetrahydrocurcumin, demethoxycurcumin and bisdemethoxycurcumin) which may strike to the root pathological cause of Alzheimer's disease by preventing β-amyloid protein formation.[15] [16] [17] [18]
   •   Neurorestorative: Curcuminoids appear to rescue long-term potentiation (an indication of functional memory) impaired by amyloid peptide, and may reverse physiological damage by restoring distorted neurites and disrupting existing plaques. [19] [20]
   •   Metal-chelating properties: Curcumin has a higher binding affinity for iron and copper rather than zinc, which may contribute to its protective effect in Alzheimer's disease, as iron-mediated damage may play a pathological role.[21] [22]
Just The Tip of the Medicine Spice Cabinet
The modern kitchen pantry contains a broad range of anti-Alzheimer's disease items, which plenty of science now confirms. Our Alzheimer's research page contains research on 97 natural substances of interest. Top on the list, of course, is curcumin. Others include:
   •   Coconut Oil: This remarkable substance contains approximately 66% medium chain triglycerides by weight, and is capable of improving symptoms of cognitive decline in those suffering from dementia by increasing brain-boosing ketone bodies, and perhaps more remarkably, within only one dose, and within only two hours.[23]
   •   Cocoa: A 2009 study found that cocoa procyanidins may protect against lipid peroxidation associated with neuronal cell death in a manner relevant to Alzheimer's disease.[24]
   •   Sage: A 2003 study found that sage extract has therapeutic value in patients with mild to moderate Alzheimer's disease.[25]
   •   Folic acid: While most of the positive research on this B vitamin has been performed on the semi-synthetic version, which may have unintended, adverse health effects, the ideal source for this B vitamin is foliage, i.e. green leafy vegetables, as only foods provide folate. Also, the entire B group of vitamins, especially including the homocysteine-modulating B6 and B12,[26] may have the most value in Alzheimer's disease prevention and treatment. 
   •   Resveratrol: this compound is mainly found in the Western diet in grapes, wine, peanuts and chocolate. There are 16 articles on our website indicating it has anti-Alzheimer's properties.[27]
Other potent natural therapies include:
   •   Gingko biloba: is one of the few herbs proven to be at least as effective as the pharmaceutical drug Aricept in treating and improving symptoms of Alzheimer's disease.[28] [29]
   •   Melissa offinalis: this herb, also known as Lemon Balm, has been found to have therapeutic effect in patients with mild to moderate Alzheimer's disease.[30]
   •   Saffron: this herb compares favorably to the drug donepezil in the treatment of mild-to-moderate Alzheimer's disease.[31]
As always, the important thing to remember is that it is our diet and environmental exposures that largely determine our risk of accelerated brain aging and associated dementia. Prevention is an infinitely better strategy, especially considering many of the therapeutic items mentioned above can be used in foods as spices. Try incorporating small, high-quality culinary doses of spices like turmeric into your dietary pattern, remembering that 'adding it to taste,' in a way that is truly enjoyable, may be the ultimate standard for determining what a 'healthy dose' is for you.
*This statement is not meant to be used to prevent, diagnosis, treat, or cure a disease; rather, it is a statement of fact: the research indexed on our database indicates it
**Our professional database users are empowered to employ the 'Advanced Database Options' listed on the top of the Turmeric research page and after clicking the function "Sort Quick Summaries by Title Alphabetically" under "Available Sorting Options" they can quickly retrieve an alphabetical list of all 613 diseases relevant to the Turmeric research, and then choosing the "Focus" articles selection to the right of the "Alzheimer's disease" heading to see only the 30 study abstracts relevant to the topic.

[1] Ron Brookmeyer, Elizabeth Johnson, Kathryn Ziegler-Graham, H Michael Arrighi. Forecasting the global burden of Alzheimer's disease. Alzheimers Dement. 2007 Jul ;3(3):186-91. PMID: 19595937

[2] Nozomi Hishikawa, Yoriko Takahashi, Yoshinobu Amakusa, Yuhei Tanno, Yosh*take Tuji, Hisayoshi Niwa, Nobuyuki Murakami, U K Krishna. Effects of turmeric on Alzheimer's disease with behavioral and psychological symptoms of dementia. Ayu. 2012 Oct ;33(4):499-504. PMID: 23723666

[3] V Chandra, R Pandav, H H Dodge, J M Johnston, S H Belle, S T DeKosky, M Ganguli. Incidence of Alzheimer's disease in a rural community in India: the Indo-US study. Neurology. 2001 Sep 25 ;57(6):985-9. PMID: 11571321

[4], Declaring Chemical Warfare Against Alzheimer's.

[5], Turmeric's Neuroprotective Properties (114 study abstracts)

[6] Laura Zhang, Milan Fiala, John Cashman, James Sayre, Araceli Espinosa, Michelle Mahanian, Justin Zaghi, Vladimir Badmaev, Michael C Graves, George Bernard, Mark Rosenthal. Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients. J Alzheimers Dis. 2006 Sep;10(1):1-7. PMID: 16988474

[7] Ava Masoumi, Ben Goldenson, Senait Ghirmai, Hripsime Avagyan, Justin Zaghi, Ken Abel, Xueying Zheng, Araceli Espinosa-Jeffrey, Michelle Mahanian, Phillip T Liu, Martin Hewison, Matthew Mizwickie, John Cashman, Milan Fiala. 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients. J Alzheimers Dis. 2009 Jul;17(3):703-17. PMID: 19433889

[8] Hongying Liu, Zhong Li, Donghai Qiu, Qiong Gu, Qingfeng Lei, Li Mao. The inhibitory effects of different curcuminoids onβ-amyloid protein, β-amyloid precursor protein and β-site amyloid precursor protein cleaving enzyme 1 in swAPP HEK293 cells. Int Dent J. 1996 Feb;46(1):22-34. PMID: 20727383

[9] Shilpa Mishra, Mamata Mishra, Pankaj Seth, Shiv Kumar Sharma. Tetrahydrocurcumin confers protection against amyloidβ-induced toxicity. Neuroreport. 2010 Nov 24. Epub 2010 Nov 24. PMID: 21116204

[10] Xiao-Yan Qin, Yong Cheng, Long-Chuan Yu. Potential protection of curcumin against intracellular amyloid beta-induced toxicity in cultured rat prefrontal cortical neurons. Neurosci Lett. 2010 Aug 9;480(1):21-4. PMID: 20638958

[11] Hong-Mei Wang, Yan-Xin Zhao, Shi Zhang, Gui-Dong Liu, Wen-Yan Kang, Hui-Dong Tang, Jian-Qing Ding, Sheng-Di Chen. PPARgamma agonist curcumin reduces the amyloid-beta-stimulated inflammatory responses in primary astrocytes. J Alzheimers Dis. 2010;20(4):1189-99. PMID: 20413894

[12] G P Lim, T Chu, F Yang, W Beech, S A Frautschy, G M Cole. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001 Nov 1;21(21):8370-7. PMID: 11606625

[13] Xiao-Yan Qin, Yong Cheng, Long-Chuan Yu. Potential protection of curcumin against intracellular amyloid beta-induced toxicity in cultured rat prefrontal cortical neurons. Neurosci Lett. 2010 Aug 9;480(1):21-4. PMID: 20638958

[14] D S Kim, S Y Park, J K Kim. Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult. Neurosci Lett. 2001 Apr 27;303(1):57-61. PMID: 11297823

[15] R Douglas Shytle, Paula C Bickford, Kavon Rezai-zadeh, L Hou, Jin Zeng, Jun Tan, Paul R Sanberg, Cyndy D Sanberg, Bill Roschek, Ryan C Fink, Randall S Alberte. Optimized turmeric extracts have potent anti-amyloidogenic effects. Curr Alzheimer Res. 2009 Dec;6(6):564-71. PMID: 19715544

[16] Fusheng Yang, Giselle P Lim, Aynun N Begum, Oliver J Ubeda, Mychica R Simmons, Surendra S Ambegaokar, Pingping P Chen, Rakez Kayed, Charles G Glabe, Sally A Frautschy, Gregory M Cole. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. Neurochem Int. 2009 Mar-Apr;54(3-4):199-204. Epub 2008 Nov 30. PMID: 15590663

[17] Can Zhang, Andrew Browne, Daniel Child, Rudolph E Tanzi. Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein. Gastroenterology. 2006 Jan;130(1):120-6. PMID: 20622013

[18] Ranjit K Giri, Vikram Rajagopal, Vijay K Kalra. Curcumin, the active constituent of turmeric, inhibits amyloid peptide-induced cytochemokine gene expression and CCR5-mediated chemotaxis of THP-1 monocytes by modulating early growth response-1 transcription factor. J Neurochem. 2004 Dec;91(5):1199-210. PMID: 15569263

[19] Touqeer Ahmed, Anwarul-Hassan Gilani, Narges Hosseinmardi, Saeed Semnanian, Syed Ather Enam, Yaghoub Fathollahi. Curcuminoids rescue long-term potentiation impaired by amyloid peptide in rat hippocampal slices. Synapse. 2010 Oct 20. Epub 2010 Oct 20. PMID: 20963814

[20] M Garcia-Alloza, L A Borrelli, A Rozkalne, B T Hyman, B J Bacskai. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J Neurochem. 2007 Aug;102(4):1095-104. Epub 2007 Apr 30. PMID: 17472706

[21] Larry Baum, Alex Ng. Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models. J Alzheimers Dis. 2004 Aug;6(4):367-77; discussion 443-9. PMID: 15345806

[22] Silvia Mandel, Tamar Amit, Orit Bar-Am, Moussa B H Youdim. Iron dysregulation in Alzheimer's disease: multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents. Prog Neurobiol. 2007 Aug;82(6):348-60. Epub 2007 Jun 19. PMID: 17659826

[23] Mark A Reger, Samuel T Henderson, Cathy Hale, Brenna Cholerton, Laura D Baker, G S Watson, Karen Hyde, Darla Chapman, Suzanne Craft. Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging. 2004 Mar;25(3):311-4. PMID: 15123336

[24] Eun Sun Cho, Young Jin Jang, Nam Joo Kang, Mun Kyung Hwang, Yong Taek Kim, Ki Won Lee, Hyong Joo Lee. Cocoa procyanidins attenuate 4-hydroxynonenal-induced apoptosis of PC12 cells by directly inhibiting mitogen-activated protein kinase kinase 4 activity. Free Radic Biol Med. 2009 May 15;46(10):1319-27. Epub 2009 Feb 25. PMID: 19248828

[25] S Akhondzadeh, M Noroozian, M Mohammadi, S Ohadinia, A H Jamshidi, M Khani. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebo-controlled trial. J Clin Pharm Ther. 2003 Feb;28(1):53-9. PMID: 12605619

[26] Celeste A de Jager, Abderrahim Oulhaj, Robin Jacoby, Helga Refsum, A David Smith. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry. 2011 Jul 21. Epub 2011 Jul 21. PMID: 21780182

[27], Resveratrol's Anti-Alzheimer's properties

[28] S Yancheva, R Ihl, G Nikolova, P Panayotov, S Schlaefke, R Hoerr,. Ginkgo biloba extract EGb 761(R), donepezil or both combined in the treatment of Alzheimer's disease with neuropsychiatric features: a randomised, double-blind, exploratory trial. Aging Ment Health. 2009 Mar;13(2):183-90. PMID: 19347685

[29] M Mazza, A Capuano, P Bria, S Mazza. Ginkgo biloba and donepezil: a comparison in the treatment of Alzheimer's dementia in a randomized placebo-controlled double-blind study. Eur J Neurol. 2006 Sep;13(9):981-5. PMID: 16930364

[30] S Akhondzadeh, M Noroozian, M Mohammadi, S Ohadinia, A H Jamshidi, M Khani. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry. 2003 Jul;74(7):863-6. PMID: 12810768

[31] Shahin Akhondzadeh, Mehdi Shafiee Sabet, Mohammad Hossein Harirchian, Mansoreh Togha, Hamed Cheraghmakani, Soodeh Razeghi, Seyyed Shamssedin Hejazi, Mohammad Hossein Yousefi, Roozbeh Alimardani, Amirhossein Jamshidi, Shams-Ali Rezazadeh, Aboulghasem Yousefi, Farhad Zare, Atbin Moradi, Ardalan Vossoughi. A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer's disease. Psychopharmacology (Berl). 2010 Jan;207(4):637-43. Epub 2009 Oct 20. PMID: 19838862

Sayer Ji is founder of, a reviewer at the International Journal of Human Nutrition and Functional Medicine, Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of the National Health Federation, Steering Committee Member of the Global Non-GMO Foundation.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

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« Reply #97 on: December 09, 2019, 05:10:54 PM »
Green Med Info is an excellent resource.  Thanks for sharing in such detail Ilinda!


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« Reply #98 on: December 17, 2019, 09:31:12 PM »
Note from Barb: I happened to stumble upon this while posting something about one of my favorite herbs, Yerba Santa. it is known to help respiratory conditions including asthma.
What I had never heard of before - Yerba Santa is good for the brain and may help Alzheimer's sufferers.

Eriodictyon californicum

Medical research
The flavonoid sterubin is the main active component of Yerba Santa and is neuroprotective against multiple toxicities of the aging brain, including possibly Alzheimer's disease.


  • Guest
« Reply #99 on: December 17, 2019, 09:36:12 PM »
RR again, thanks for all the research and wonderful ideas about brain health! Readers: Please see RR's Reply #2, 3, 4, 6, 11 and possibly others.

RR and ilinda have both posted some items worth reading and re-reading.


  • Guest
« Reply #100 on: December 24, 2019, 02:59:46 PM »

The above 12-part series is being rebroadcast this weekend, actually for four days, IIRC.  It is worth watching, if you have memory problems, or if you know someone with memory issues.  It's free so enjoy.


  • Guest
« Reply #101 on: January 09, 2020, 02:35:28 PM »
“90 Per Cent of Alzheimer’s Cases Are Preventable”

Learn all about the only scientifically proven solution to the international epidemic of Alzheimer’s disease.

By Dean and Ayesha Sherzai, M.D., Co-directors of the Brain Health and Alzheimer’s Prevention Program at Loma Linda University Medical Center
Excerpted from The Alzheimer’s Solution: A Breakthrough Program to Prevent and Reverse the Symptoms of Cognitive Decline at Every Age
If you would have told us fifteen years ago that we’d be writing the first book about the only scientifically proven solution to the international epidemic of Alzheimer’s disease, we never would have believed you.

Fifteen years ago, we were young neurologists practicing medicine the way we’d been taught. We were hopeful that the billions of dollars donated to fund Alzheimer’s research would soon result in a cure, some kind of pill that could affect the pathology we’d learned so much about. We pursued the most prestigious fellowships in our field—at the National Institutes of Health and University of California, San Diego—and worked with leading researchers at the forefront of the fight against Alzheimer’s. We wanted to find a solution. And we did, eventually—just not the solution we expected.

It was during those fifteen years that we conducted one of the most comprehensive studies on the incidence of dementia, and designed a groundbreaking protocol for Alzheimer’s treatment and prevention.

Our work began at Loma Linda University and then took us to Cedars-Sinai in Los Angeles before we returned to Loma Linda to continue our research and serve communities throughout Southern California and beyond. And it was during those fifteen years that we treated thousands of patients suffering from mild cognitive impairment to Alzheimer’s disease with our innovative NEURO Plan, helping them reverse symptoms, prevent further decline, add years to their lives, and change the trajectory of their health.

So many of these patients shared their stories with us. They told us that their parents or grandparents had Alzheimer’s and that developing the disease themselves was their single greatest fear. They told us about the humiliation of having to rely on caregivers to meet their basic needs.

They’d assumed there was no treatment, that they would be ostracized if others found out about their condition. Some of these patients were having trouble remembering names or had gotten lost in a familiar place. Some of them already had a formal Alzheimer’s diagnosis when they arrived at our clinic, unable to express themselves or recognize their loved ones.

If this sounds familiar to you, we want you to know there is hope. There is a way to prevent cognitive decline, to slow its progression and improve quality of life for those who already have a diagnosis.

What conventional medicine hasn’t told you or your loved ones, or any of the nearly six million people living with Alzheimer’s in the United States, or the forty-seven million people living with Alzheimer’s worldwide, is that within the normal life span, 90 percent of Alzheimer’s cases can be prevented.

This figure bears repeating: 90 percent of grandparents, parents, husbands, and wives should have been spared. Ninety percent of people living with Alzheimer’s or dementia didn’t have the resources or knowledge they needed to prevent this devastating disease.

Ninety percent of us can avoid ever getting Alzheimer’s, and for the rest of us, the 10 percent with strong genetic risk for cognitive decline, the disease can potentially be delayed by ten to fifteen years.

This isn’t just an estimate or wishful thinking: it’s a figure based on rigorous science and the remarkable results we’ve seen in our clinic.
As it turns out, the solution to Alzheimer’s has been hiding in plain sight. We now know that Alzheimer’s disease and overall cognitive health are deeply influenced by five main lifestyle factors represented by the acronym NEURO—Nutrition, Exercise, Unwind, Restore, and Optimize.
Direct links exist between poor nutrition, lack of exercise, chronic stress, poor sleep, the extent to which we challenge and engage our brains and neurodegenerative disease.

The truth is that the choices we make every day determine our cognitive fate—but there is almost no awareness of this crucial fact, despite the veritable crisis we’re in when it comes to Alzheimer’s.

The 5 aspects of a healthy lifestyle that form the heart of our unique NEURO Plan:
   •   Nutrition: A whole-food, plant-based diet low in sugar, salt, and processed foods.
   •   Exercise: An active lifestyle that incorporates movement every hour— not just a stop at the gym after an otherwise sedentary day.
   •   Unwind: Stress management in the form of meditation, yoga, mindful breathing exercises, time spent in nature, and the support of strong communities.
   •   Restore: Seven to eight hours of regular, detoxifying sleep through intensive sleep hygiene, treatment for sleep disorders, and management of medications and foods that adversely affect sleep.
   •   Optimize: Multimodal activities (like music) that challenge and engage many of the brain’s capacities, as well as meaningful social interaction.
While it may be easier to blame a devastating disease like Alzheimer’s on a single gene, this false belief is killing millions. The truth is much harder to accept—that we are bringing Alzheimer’s disease into our households through the choices we make every day. But the truth is also liberating because it puts control back in our hands.

There were also other findings at the clinic—results that were almost unbelievable. We worked with a patient who had a bad habit of eating cookies and cake. Her glycated hemoglobin level was 13 (as revealed by an HbA1c blood test, which measures average blood sugar over a period of three months); a score of 6.5 or above is considered diabetic. She was beginning to forget names and struggle with simple tasks at her job, both of which were creating great anxiety. We helped her reform her diet and after three months, her HbA1c had plummeted to 6. Even more shockingly, she said her brain fog had lifted.

Another patient started walking around his neighborhood each morning and reported that he was thinking more clearly than he had in decades. A follow-up neuropsychological test confirmed that his memory had in fact improved. One woman in the early stages of cognitive decline was suffering from white matter disease (deterioration of white matter, a type of brain tissue). One year after she adopted a plant-based diet, an MRI revealed improvements in the size of her hippocampus. Our patients were showing us over and over that lifestyle could not only slow the progression of Alzheimer’s disease, but even reverse cognitive symptoms. Lifestyle was not just prevention: it was a potential treatment.

As the co-directors of the Brain Health and Alzheimer’s Prevention Program at Loma Linda University, we’ve guided thousands of people through the highly personalized process of lifestyle change.

We now have hundreds of these remarkable stories.
Behind all the science, behind all the statistical analysis and the papers published year after year in well-respected journals, is the plate of food on the table. The biggest factor in our long-term health is what we choose to eat three to four times per day.

Food determines the fate of our bodies—how we grow, how we age, and how we die. What we eat every day creates and re-creates both our cells and their supporting structures. What we fail to eat causes deficiencies that stress and traumatize the body. Though the brain comprises only 2 percent of the body by weight, it uses up to 25 percent of the body’s energy, and because food is energy, our brains are especially vulnerable to each nutritional choice we make.

We can think of food as a type of environmental exposure through which we set up the potential for health or the potential for disease. What you choose to eat creates either an environment in which the brain can thrive and repair itself, or an environment that promotes decline.
Some researchers have argued that Alzheimer’s is essentially a garbage disposal problem, the brain’s inability to cope with what we feed it over a lifetime. Poor nutrition damages the brain in so many ways: it causes inflammation and the buildup of oxidative by-products, clogs blood vessels, and deprives your brain of the nutrients it needs to strengthen neurons, their connections, and critical support structures.

Because of its fundamental role in sustaining and regenerating the body, food is the single greatest tool we have in the fight against Alzheimer’s. As lifestyle physicians and researchers, we cannot overstate the importance of food for brain health: it is by far the most important lifestyle factor.

The dietary choices we make every day influence the prevention, delay, or progression of cognitive decline. Our clinical research has shown again and again, with patients of all ages and degrees of neurodegenerative disease, that adhering to a brain-healthy diet results in better cognition. It’s that simple.

Or is it? We all know we should eat “healthy.” We know that vegetables are a better choice than cake, that we should avoid sodas and sugary drinks and anything called “fast food.”  Most of us know that the steady increase in our consumption of processed foods over the past fifty years has led to an epidemic of obesity, heart disease, and diabetes. But many of us don’t understand the direct connection between food and the brain.

There is an assumption—perpetuated by scientists, researchers, and even doctors—that the brain is too complex to be in influenced by our daily actions, that it’s somehow not part of the physical body. Many of our patients accept that alcohol consumption poisons the liver. Studies have proven that smoking causes lung cancer. Yet most patients have trouble accepting that the cognitive symptoms they’re experiencing could be the result of something as simple as food.

The brain is damaged exponentially by poor nutritional choices, more so than all other bodily systems given how hard it works, how much energy it consumes, and how much waste it’s responsible for clearing. Cognitive health is intrinsically linked to overall health, and when we fail to nourish our bodies, we also fail to nourish our brains. The inverse is true as well: giving our bodies the right foods protects and strengthens our brains.

Nutrition is unique in that it creates more anxiety and confusion than any other lifestyle factor in the NEURO Plan. With all of the overwhelming and contradictory information about nutrition, it might seem nearly impossible to come up with a plan that you feel confident is contributing to your overall health, let alone your brain health.

One website tells you to cut out carbohydrates. Your doctor, in a hurried appointment without much time for questions, says you should eat less meat—but how much is “less”?  Then you read a book that says some, but not all carbohydrates, are essential. A good friend tells you that fat is now considered healthy. A magazine article claims that vegetarian diets don’t provide all the protein you need.

Despite your frustrations and your very busy life, you do the best you can. You adopt a heart-healthy diet. You try to lose weight. You make a concerted effort to eat more vegetables and buy fewer pre-packaged foods, and hope that will be enough. If you’re in the midst of this struggle yourself, you’ve come to the right place.

Though current research points to an ideal diet for brain health—a whole-food, plant-based, low-sugar diet with little meat and dairy—numerous studies have also proven that incremental steps toward brain-healthy eating have tremendous benefits. Please keep this important concept in mind as you read. The goal is not necessarily to eat perfectly for the brain, but to figure out the best, most sustainable diet for you based on verified research and your unique circumstances.

Excerpted from The Alzheimer’s Solution: A Breakthrough Program to Prevent and Reverse the Symptoms of Cognitive Decline at Every Age. Get the whole book here.


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« Reply #102 on: January 09, 2020, 02:40:00 PM »

The above 12-part series is being rebroadcast this weekend, actually for four days, IIRC.  It is worth watching, if you have memory problems, or if you know someone with memory issues.  It's free so enjoy.
A main message I got from viewing the series is that there are many, many causes of dementia, and if not corrected, the condition will continue until it's too late to reverse it.  Memory loss is not a static thing, and that is why it is so critical to discover the specific cause(s) of a given case of dementia or Alz. Dis.

For example, some of the causes are vitamin B12 deficiency, ingestion of trans fats, exposure to wi fi, hypothyroidism, and many more.  Some of these doctors do really extensive testing to determine the cause, and once determined, it can nearly always be reversed, by eliminating the condition that is causing it.


  • Guest
« Reply #103 on: January 09, 2020, 06:07:40 PM »

The above 12-part series is being rebroadcast this weekend, actually for four days, IIRC.  It is worth watching, if you have memory problems, or if you know someone with memory issues.  It's free so enjoy.

ilinda, thanks for posting this info, so very much needed by so many people...


  • Guest


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