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Author Topic: ALZHEIMERS - BRAIN HEALTH posts  (Read 20465 times)

R.R. Book

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #30 on: November 09, 2017, 07:19:10 AM »
Some examples off-hand of questionable advice broadly disseminated:

1. Salt is bad, including sea salt

2. Eggs are bad

3. Whole grains should be eaten exclusively.

4. Fructose as a sugar-substitute is good

5. Fats are bad

6. Cholesterol is bad

7. Cholesterol tests measure cholesterol

8. Bt is good for the soil of gardens that grow food

9. Butter is bad

10. Gelatinized broth is bad

11. Store-bought broth is the same as home-made

12. Expect to get all the minerals you need from food

13. Chocolate is mostly healthy

14. Sugar-alcohols are good

15. Unpasteurized milk is bad

16. All the iodine we need is in salt.

17. Lard is bad

18. Bt is a good idea to insert into papaya genes

19. Soy is good

20. Soy is even better genetically modified

Will probably get hate mail from #13 :)

Jimfarmer

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #31 on: November 09, 2017, 10:26:11 AM »
Quote
13. Chocolate is mostly healthy
...
Will probably get hate mail from #13 :)

*#!   >:(

Well, I understood that the cocoa component is healthful.  Do you have some contrary info?

R.R. Book

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #32 on: November 09, 2017, 02:56:08 PM »
Alpha-Lipoic Acid (ALA, not to be confused with alpha-linolenic acid which is also abbreviated ALA) has been shown to influence brain functioning via at least two mechanisms: direct effect upon the nervous system, and via prevention of diabetes, which as we discussed earlier is a primary cause of Alzheimer's Disease.

An early 1995 German study found that ALA supplementation resulted in a "significant increase" of glucose disposal due to improved insulin sensitivity: https://www.ncbi.nlm.nih.gov/pubmed/7575750
 
 A 2005 Korean animal study says that ALA prevents the onset of diabetes: https://www.ncbi.nlm.nih.gov/pubmed/15913551

A 2005 animal study by American researchers reviewed the correlation between free-radical damage and Alzheimer's Disease.  The study concluded that ALA restores normal proteins in the brain, leading to improved learning and memory.  https://www.ncbi.nlm.nih.gov/pubmed/15627516

A 2006 German animal study using three dosing levels vs. an un-dosed control group determined that mortality was lower for all three groups receiving ALA when compared to the control set.  The study also found that the treated groups thrived on less food by their own choice.  https://www.ncbi.nlm.nih.gov/pubmed/?term=Long-term+safety+of+alpha-lipoic+acid+(ALA)+consumption%3A+A+2-year+study.

A 2009 animal study by American investigators found that ALA increases anti-oxidant defenses in aging brain mitochondria, concluding that the supplement "partially or completely" restored mitochondrial health, suggesting that supplementation might be "an effective strategy for delaying brain aging." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790461/

A 2014 Korean study stated that levels of endogenous alpha-lipoic acid "significantly decline with age."  https://www.ncbi.nlm.nih.gov/pubmed/25005184

A 2014 Chinese study found that ALA enhances insulin sensitivity in the liver and assists with glucose metabolism (which as we've seen elsewhere is at the root of protection from AD).  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186984/

A 2014 American study demonstrated protective neurological effects of ALA, as well as possible use of the supplement in lieu of anti-viral drugs for viral diseases of the CNS.  https://www.ncbi.nlm.nih.gov/pubmed/24269587/

Another 2014 American study that was randomized and placebo-controlled, utilizing both omega-3 essential fatty acids and ALA, found that both cognitive and functional decline were slowed in mild to moderate levels of AD impairment.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886557/

A 2014 Russian study abstract summarized that ALA showed anti-oxidant and neuroprotective effects against diseases of the central nervous system.  The abstract further stated that it was well-tolerated by patients, concluding that there were "grounds for wide application...in neurological practice."  https://www.ncbi.nlm.nih.gov/pubmed/25632426

As an unrelated post-script, this 2010 Korean study found ALA to suppress allergies and even anaphylactic responses:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026184/

« Last Edit: November 10, 2017, 04:44:36 AM by R.R. Book »

R.R. Book

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #33 on: November 09, 2017, 03:17:21 PM »
Quote
Quote

    13. Chocolate is mostly healthy
    ...
    Will probably get hate mail from #13 :)


*#!   >:(

Well, I understood that the cocoa component is healthful.  Do you have some contrary info?

Sorry to be the bearer of bad tidings Jim, but inflammation indexes rate chocolate as highly inflammatory, though it does contain anti-oxidants :)

R.R. Book

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #34 on: November 10, 2017, 03:11:38 PM »
NADH, short for the reduced form of Nicotinamide adenine dinucleotide (NAD+), is the metabolically active form of vitamin B3, also sometimes called NAD(P)H.  CoQ10 is an enzyme form of NADH.  PubChem explains that NADH is converted into ATP energy which is necessary for life, and is part of the electron transport chain. 

Studies have found supplementation of NADH may be useful in addressing dementia accompanying Alzheimer's Disease as well as Parkinson's Disease, which can have some aspects in common with AD. A disambiguation of the two diseases should precede discussion of supplementation:

A 2004 British MRI study which sought to distinguish biometrically between the two diseases mentioned above found that both illnesses at their worst involved brain atrophy, but with differing locations affected:
Parkinson's Disease without dementia: loss of frontal gray matter (balance and movement center), no atrophy
Parkinson's Disease with Dementia: loss of gray matter progressing front to rear, with occipital lobe (the visual cortex) atrophy in the rear.
Alzheimer's Disease: temporal lobe atrophy (memory/language/emotion processing center) at the sides
Dementia with Lewy Bodies: Closely accompanies some early Parkinson's Disease diagnoses, while alternatively Parkinson's Disease with Dementia follows at least one year after PD diagnosis. DLB resembles AD in several aspects, and is distinguished by abnormal spherical protein deposits
https://www.ncbi.nlm.nih.gov/pubmed/14749292




An early 1985 study further breaks down Alzheimer's Disease into AD vs. Senile Dementia of the Alzheimer's Type (SDAT). AD patient brains had normal levels of an NADH enzyme (coQ10), while SDAT patient brains had abnormally high levels plus abnormally high numbers of astrocytes in the forebrain, causing researchers to suspect a difference in energy metabolism between the two diseases (see photo).  https://www.ncbi.nlm.nih.gov/pubmed/3838807

Astrocytes
---------------------------------------------------------------------------------------------------------
A 1996 small-scale Austrian study in Alzheimer's Disease patients found supplementation with NADH to improve assessment scores across the board.  https://www.ncbi.nlm.nih.gov/pubmed/8834355

A 2009 Italian study stated that AD is the most common form of dementia in the elderly.  It also asserted that Alzheimer's Disease is primarily not disease of genetic predisposition, but that it is caused by epigenetic switching affecting production of the enzyme form of NADH (coQ10).  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925259/

A 2011 Swiss study of late-stage Alzheimer's Disease found that beta-amyloid placques invade both the interior and exterior of mitochondrial cells, limiting the ability of NADH to provide electrons, stalling the electron transport chain and altering the electrical potential of the mitochondrial membrane, in a vicious cycle.  Neurons differ from other cells in that non-neuron cells are able to produce energy from dietary glucose.  Since neurons can't feed themselves the same way, they depend entirely upon energy from ATP via NADH in the mitochondria.  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3226305_alzrt74-1&req=4

A 2013 American study stated that NADH can influence epigenetic switching.   https://pubs.niaaa.nih.gov/publications/arcr351/6-16.htm

A 2014 American study said that NAD+ (the precursor of NADH) levels decline during the aging process, leading to a cascade of aging-related diseases, including decreased expression of longevity genes called sirtuins.  Researchers concluded that supplementation with substrates of NAD+ could positively impact a variety of age-related diseases.  Such substrates might include nicotinamide mononucleotide (NMT) or nicotinamade riboside (NR), both forms of vitamin B3.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112140/

Parenteral supplementation studies in the 1990's proved the NADH of that period to be ineffective, due to shelf-life instability of NADH tablet processing methods in that era (they literally lost all potency within a few weeks of being produced) and due to lack of bio-availability via the digestive tract.  Then beginning in 2002, a new method of processing oral NADH  to protect it from the digestive tract and endow it with a stable shelf-life, called the Enada method, produced the first usable supplement on the market, and several supplement companies have copied the method.  Dosages range from 5-25 mg, with 10 mg daily being considered safe for longer term usage.  The higher range is best taken in the morning, as it may cause insomnia.

Later in 2015 two small companies further improved oral supplementation by attaching the NADH molecule to ADP-ribose under the supervision of several Nobel Laureates, according to Scientific American (David Stipp, March 11, 2015: "Beyond Resveratrol: The Anti-Aging NAD Fad.").  The two new supplements are marketed under the names of Niagen by ChromaDex and Basis by Elesium Health. 

Finally an actual clinical trial of this new kind of NADH on humans was also completed in 2015 - this was the first human clinical trial since the parenteral trial in the 1990's.  It demonstrated statistically significant increases in endogenous NAD+ levels in healthy subjects from a single dose of the ribose form of supplemental nicotinamide.  No safety issues  appeared, and the effective dosage range was found.  https://www.ncbi.nlm.nih.gov/pubmed?term=niagen&cmd=correctspelling




« Last Edit: November 10, 2017, 03:59:48 PM by R.R. Book »

Yowbarb

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #35 on: November 12, 2017, 06:49:41 AM »
Maybe we should think about starting a whole thread about how doing the opposite of what the MD says has been good for our health.

One example that I can recall:  I was hospitalized 8 years ago when my esophagus swelled shut, and given two bad pieces of advice by the attending in-house physician:

1. plan to do off-label oral use of albuterol inhalers in which the mist is swallowed instead of being inhaled (he was hoping to put me in a clinical trial without my permission I later discovered)
2. don't bother getting an allergy test

I visited an allergist instead and after 18 months of process of elimination, the swelling was attributed to GMO corn.  Apparently I'm sensitive to the Bt inserted into the corn genes.

So glad I disobeyed Dr.'s orders :)

Wow, RR! I am so glad you survived that...
I also think some of my worst episodes in the past might  have been from some GM food.
Back about 2005 I sat up all night and traced articles back...two Japanese scientists determined that for some people consuming GM products (bacteria, rat, bug genes spliced in, etc.) some people that is enough to cause their bodies to generate killer T cells. Enough to kill the person.
« Last Edit: November 12, 2017, 07:34:02 AM by Yowbarb »

Yowbarb

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #36 on: November 12, 2017, 06:55:24 AM »
Maybe we should think about starting a whole thread about how doing the opposite of what the MD says has been good for our health.

One example that I can recall:  I was hospitalized 8 years ago when my esophagus swelled shut, and given two bad pieces of advice by the attending in-house physician:

1. plan to do off-label oral use of albuterol inhalers in which the mist is swallowed instead of being inhaled (he was hoping to put me in a clinical trial without my permission I later discovered)
2. don't bother getting an allergy test

I visited an allergist instead and after 18 months of process of elimination, the swelling was attributed to GMO corn.  Apparently I'm sensitive to the Bt inserted into the corn genes.

So glad I disobeyed Dr.'s orders :)

RR, just to understand better did the doctor have you using albuterol, (and did you do that with the swallowing of the mist?)
If you were on albuterol, were you able to put it down, go off it at a later time?

Yowbarb

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #37 on: November 12, 2017, 07:30:13 AM »
Alpha-Lipoic Acid (ALA, not to be confused with alpha-linolenic acid which is also abbreviated ALA) has been shown to influence brain functioning via at least two mechanisms: direct effect upon the nervous system, and via prevention of diabetes, which as we discussed earlier is a primary cause of Alzheimer's Disease.

An early 1995 German study found that ALA supplementation resulted in a "significant increase" of glucose disposal due to improved insulin sensitivity: https://www.ncbi.nlm.nih.gov/pubmed/7575750
 
 A 2005 Korean animal study says that ALA prevents the onset of diabetes: https://www.ncbi.nlm.nih.gov/pubmed/15913551

A 2005 animal study by American researchers reviewed the correlation between free-radical damage and Alzheimer's Disease.  The study concluded that ALA restores normal proteins in the brain, leading to improved learning and memory.  https://www.ncbi.nlm.nih.gov/pubmed/15627516

A 2006 German animal study using three dosing levels vs. an un-dosed control group determined that mortality was lower for all three groups receiving ALA when compared to the control set.  The study also found that the treated groups thrived on less food by their own choice.  https://www.ncbi.nlm.nih.gov/pubmed/?term=Long-term+safety+of+alpha-lipoic+acid+(ALA)+consumption%3A+A+2-year+study.

A 2009 animal study by American investigators found that ALA increases anti-oxidant defenses in aging brain mitochondria, concluding that the supplement "partially or completely" restored mitochondrial health, suggesting that supplementation might be "an effective strategy for delaying brain aging." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790461/

A 2014 Korean study stated that levels of endogenous alpha-lipoic acid "significantly decline with age."  https://www.ncbi.nlm.nih.gov/pubmed/25005184

A 2014 Chinese study found that ALA enhances insulin sensitivity in the liver and assists with glucose metabolism (which as we've seen elsewhere is at the root of protection from AD).  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186984/

A 2014 American study demonstrated protective neurological effects of ALA, as well as possible use of the supplement in lieu of anti-viral drugs for viral diseases of the CNS.  https://www.ncbi.nlm.nih.gov/pubmed/24269587/

Another 2014 American study that was randomized and placebo-controlled, utilizing both omega-3 essential fatty acids and ALA, found that both cognitive and functional decline were slowed in mild to moderate levels of AD impairment.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886557/

A 2014 Russian study abstract summarized that ALA showed anti-oxidant and neuroprotective effects against diseases of the central nervous system.  The abstract further stated that it was well-tolerated by patients, concluding that there were "grounds for wide application...in neurological practice."  https://www.ncbi.nlm.nih.gov/pubmed/25632426

As an unrelated post-script, this 2010 Korean study found ALA to suppress allergies and even anaphylactic responses:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026184/

RR what an eye opener your post is...
I had heard of the ALA Alpha Lipoic Acid but not read up on it.
It turns out, the ALA along with high omega 3 diet is great for the brain and slows degenerative diseases of the brain.
In this article it did state, not easy to get enough in foods, the amount in regular meats is negligible and they are not so sure about the bio-availability of the plant sources.
Supplementation is suggested with several ideas on this... The site suggests stabilized R-Lipoic Acid, and it is cheap, available Amazon prime. (PLS Note I do not know if this is good, feel it probably is, feel free to comment or post a product you use.) 

All that said, may as well include some foods regularly which are known to have some ALA:


https://www.superfoodly.com/top-10-list-of-foods-high-in-alpha-lipoic-acid-ala/

Top 10 List of Foods High In Alpha Lipoic Acid (ALA)
SuperfoodlySeptember 21, 2017


Yowbarb

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #38 on: November 12, 2017, 08:01:06 AM »
Quote
13. Chocolate is mostly healthy
...
Will probably get hate mail from #13 :)

*#!   >:(

Well, I understood that the cocoa component is healthful.  Do you have some contrary info?

Jim, RR, I'm going to weigh in on this, not claiming to be an expert.  ;)
After years of having gone off substances such as coffee, chocolate, thinking it was bad then going back on it, I feel chocolate (the cacao) is a medicine and small regular amounts of it are indeed good.
Studies in Sweden show particularly good for women's cardiovascular health...
My cardio health is good and for whatever reason since I have allowed these things back into my lifestyle, I haven't had sudden health emergencies... This is very subjective, I realize...
For anyone who does feel chocolate it is bad, that's OK. I am not saying you are wrong... it just doesn't appear to be bad for me...
Chocolate will be a part of my world as long as I can get my hands on it.
 8)


 



R.R. Book

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #39 on: November 12, 2017, 09:20:24 AM »
Power to you and Jim both Barb!  Am guessing that many things are probably fine to eat in smaller amounts that might otherwise pose some people a health challenge.   :)

For those with cystic ovaries who may want to shrink the cysts without having them surgically removed, chocolate is eliminated from the diet.  Several websites cover this info.  Chocolate is also contraindicated for those prone to forming stones, particularly oxalate stones, and in those cases, even small amounts can create problems.

R.R. Book

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #40 on: November 12, 2017, 09:31:35 AM »
Barb, thanks for the food list for ALA - I'm a big fan of buttered Brussels sprouts, though others might not like them! :)

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #41 on: November 12, 2017, 09:48:41 AM »
Quote
RR, just to understand better did the doctor have you using albuterol, (and did you do that with the swallowing of the mist?)
If you were on albuterol, were you able to put it down, go off it at a later time?

Barb, Shortly after the attending in-house physician left that prescription with the nursing station and departed, two members of the hospital respiratory therapy staff came into my room and rather vehemently advised me not to follow his orders, saying that swallowing the mist would cause it to be sent to the liver for processing, and no studies had been done on that application of the inhaler.  So I followed their advice, and when the swelling had gone down enough, I was released to go home and then sought the allergist's help instead.  Because the esophageal swelling was not a direct allergy, his tests were unhelpful at first, as allergies to things that I didn't eat were the only test results.  However, the elimination diet did eventually reveal GMO corn as the root of the problem, when I tested negatively to a corn allergy but my esophagus would clearly swell within hours of eating non-organic corn products.  The name of the diagnosis was "Eosinophilic Esophagitis."

Interestingly, another more knowledgeable physician on duty in the hospital had mentioned to me that a number of patients were presenting themselves for treatment of a swollen esophagus, and he did say that it was known that something relatively new had been introduced into the environment which was suspected of causing the reaction.  He did not elaborate, and at that early date, probably not enough data was available on specific health hazards of GMO products.

Yowbarb

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #42 on: November 12, 2017, 10:42:32 AM »
Quote
RR, just to understand better did the doctor have you using albuterol, (and did you do that with the swallowing of the mist?)
If you were on albuterol, were you able to put it down, go off it at a later time?

Barb, Shortly after the attending in-house physician left that prescription with the nursing station and departed, two members of the hospital respiratory therapy staff came into my room and rather vehemently advised me not to follow his orders, saying that swallowing the mist would cause it to be sent to the liver for processing, and no studies had been done on that application of the inhaler.  So I followed their advice, and when the swelling had gone down enough, I was released to go home and then sought the allergist's help instead. 

That is very fortunate that those hospital staff intervened...

Yowbarb

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #43 on: November 12, 2017, 10:45:13 AM »
Quote
RR, just to understand better did the doctor have you using albuterol, (and did you do that with the swallowing of the mist?)
If you were on albuterol, were you able to put it down, go off it at a later time?

...when the swelling had gone down enough, I was released to go home and then sought the allergist's help instead.  Because the esophageal swelling was not a direct allergy, his tests were unhelpful at first, as allergies to things that I didn't eat were the only test results.  However, the elimination diet did eventually reveal GMO corn as the root of the problem, when I tested negatively to a corn allergy but my esophagus would clearly swell within hours of eating non-organic corn products.  The name of the diagnosis was "Eosinophilic Esophagitis."

Interestingly, another more knowledgeable physician on duty in the hospital had mentioned to me that a number of patients were presenting themselves for treatment of a swollen esophagus, and he did say that it was known that something relatively new had been introduced into the environment which was suspected of causing the reaction.  He did not elaborate, and at that early date, probably not enough data was available on specific health hazards of GMO products.

RR I would imagine there are lots of medical practitioners who really have no clue the root cause of some of the problems occurring...

Thankfully you yourself have the intelligence to help protect your self..
It's not so easy and for many they are not able to get the medical intervention and/or figure it out on time. So  they lose their lives due to some unknown carcinogen radiation or GM... 

So glad you are still here.

R.R. Book

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #44 on: November 12, 2017, 02:39:13 PM »
Creatine is an amino acid that binds to phosphorus to contribute toward production of ATP energy , while creatinine is the waste product excreted in urine.  It is synthesized in the body if adequate substrates are present, including arginine, glycine, and methionine. https://pubchem.ncbi.nlm.nih.gov/compound/creatine#section=Top

A 2003 Australian double-blind, placebo-controlled study supplementing oral creatine to young adults found "significant positive effect" on working memory and intelligence tests requiring speed.  Consumption of meat in the diet contributes positively to adequate creatine levels in the body, but vegetarians who supplement may also achieve high enough levels.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1691485/pdf/14561278.pdf  and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1691485/

A 2004 Italian study established the safety of creatine use even at high doses.  https://www.ncbi.nlm.nih.gov/pubmed/15758854

A 2007 British placebo-controlled trial gave a high dose of creatine (20 g / day) to an aged test pool, and found "a significant effect," concluding that creatine supplementation was cognitively beneficial to the elderly.  https://www.ncbi.nlm.nih.gov/pubmed/17828627/

A 2011 South Korean study on the safety of creatine found that neither liver nor kidney side-effects were found in either young or old test subjects following several months of supplementation.  As a safety measure, upper dosage recommendations were set at under 3-5 grams per day for anyone with impaired renal functioning, but persons with normal kidneys need not be concerned.  https://www.ncbi.nlm.nih.gov/pubmed/21399917
 
A 2011 American study said that creatine protects the CNS against both beta-amaloid toxicity and excitotoxicity.  It further found that creatine "produced an extension of survival," as well as enhancing motor performance and preventing neuron loss.  In addition, it was discovered that combining creatine with coQ10 prevented several types of neurodegeneration associated with aging, theoretically by stabilizing the mitochondria. https://www.ncbi.nlm.nih.gov/pubmed/21448659

 

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