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Author Topic: MYCOBACTERIAL INFECTIONS  (Read 490 times)

Yowbarb

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MYCOBACTERIAL INFECTIONS
« on: May 13, 2019, 03:46:00 AM »
Yowbarb Note: I was not familiar with this type of bacteria, was randomly searching about tuberculosis symptoms and etc. and found that mycobacteria are a type of bacteria which cause tuberculosis and other infections. There are tuberculosis mycobacteria and there are non tuberculosis mycobacteria. Been researching more since I think I have the NTM, non tuberculosis bacterial infection (pulmonary, sinus bronchial, lungs) also I want to share whatever I learn and post it here.

Please add your experiences and what you know.

NTM infections are spreading now, in water and dirt and are infectious but NOT contagious.
I will be posting more tomorrow.

People with previous or chronic respiratory problems such as copd asthma lung infections, bronchiestasis are more prone to the NTM.

Survival groups need to stock up on the vinegar. Why?
I just found out VINEGAR effectively kills the mycobacteria, talking about on clothing, for cleaning and etc. Whether or not consuming the vinegar helps not sure yet, but I will be adding more vinegar again to my diet. I started a VINEGAR Topic. as many of you know, vinegar has been used as  nutrition and cleaning and protection from illness for many thousands of years.
...

https://www.epa.gov/sites/production/files/2015-10/documents/mycobacteria-factsheet.pdf
.....................................................................
Mycobacteria definition

Medical Definition of Mycobacterium
Privacy & Trust Info

Mycobacterium: A large family of bacteria that have unusually waxy cell walls that are resistant to digestion.

The mycobacteria includes:

Mycobacterium avium -- which causes tuberculosis-like illness in birds and immunodeficient people;
Mycobacterium leprae -- which causes leprosy;
Mycobacterium marinum -- which causes swimming pool granuloma;
Mycobacterium tuberculosis -- which causes tuberculosis; and
Mycobacterium ulcerans -- which causes Buruli ulcer.
The mycobacteria are acid-fast rod-shaped bacteria. They are usually slow-growing. Many are intracellular parasites.

CONTINUE SCROLLING OR CLICK HERE FOR RELATED ARTICLE  https://www.medicinenet.com/mycobacterium_marinum/article.htm
Reviewed on 12/21/2018

Yowbarb

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Re: MYCOBACTERIAL INFECTIONS
« Reply #1 on: May 13, 2019, 03:51:55 AM »
Copying here some notes, quickly put together about two weeks ago:

NTM Nontuberculous Mycobacteria

https://www.healthlabs.com/?pid=9012384&iid=&gclid=Cj0KCQjw2IrmBRCJARIsAJZDdxAeOzAc93JsuDRKVArzsTOGlh-aQREeqJkRjxLoLlpINpjLFKIVXqQaAk2YEALw_wcB

NOTE:
Treatment of MAC and M kansasii, the most common causes of pulmonary NTM disease, requires three drugs given either 3 days a week or daily, depending on the severity of disease. Source is https://www.sciencedirect.com/science/article/pii/S135964461830045X#bbib0070

https://www.aboutntm.com/about-ntm-support/AboutNTM_Discussion_Guide.pdf

https://www.mdmag.com/medical-news/fatal-nontuberculosis-mycobacteria-are-not-contagious-but-still-infectious-
“Unlike TB, which is spread from person to person, NTM is not contagious”
Nontuberculous mycobacterial lung infection is often misdiagnosed. ... The diagnosis of NTM lung disease involves the following: Sputum tests (smear andculture) – sputum is examined under a microscope in an acid fast bacilli (AFB) smear, then grown in a culture. These are the basic tests to identify mycobacteria.

NTM Lung Disease Diagnosis | NTM Bacteria Testing | NTMir

https://www.ntminfo.org/how-is-ntm-diagnosed/   
1.   Sputum tests (smear and culture) – sputum is examined under a microscope in an acid fast bacilli (AFB) smear, then grown in a culture. These are the basic tests to identify mycobacteria. For accurate identification of the strain of bacteria and drug sensitivities, testing should be done at a highly specialized laboratory, which can tell your doctor which drugs will work (drug sensitivity) and which ones will not work (drug resistance) on the strain of NTM that you have. Equally important is the need to determine which combination of drugs must be used in order to minimize risk of developing drug resistance, which is a common problem when NTM infections are treated with single drug therapies. If you have trouble coughing up sputum (also called mucus or phlegm), your doctor may decide to perform a bronchoscopy to obtain the needed sample.
2.   Chest CT (computed tomography) – A CT (CAT) scan is a three-dimensional image generated from a large series of two-dimensional x-ray images. Chest x-rays alone provide rudimentary identification of lung ailments and are not sufficient. A CT scan provides the doctor with a detailed look at the extent and location of disease and is an important diagnostic tool. It can show mucus-filled airways, which appear as white spots on the images (sometimes referred to as “tree-in-bud” because of their branch-like appearance). NTM diagnosis and follow-up generally requires a high-resolution CT scan without contrast.

 
•   Learn about Nontuberculous Mycobacteria (NTM) (American Lung Association)
•   Nontuberculous Mycobacteria (NTM) (National Jewish Health)

https://www.lung.org/lung-health-and-diseases/lung-disease-lookup/nontuberculosis-mycobacteria/ntm-symptoms-causes-risks.html
NTM Symptoms, Causes & Risk Factors
The symptoms caused by NTM infection can vary from no symptoms to severe cough, fatigue, and weight loss. NTM disease is more common in individuals with underlying lung disease or weak immune systems.
What Are the Symptoms of NTM Lung Infections
Not everyone with NTM pulmonary disease has symptoms, but most have a combination of lung and other symptoms. The more severe the infection, the more likely you will have symptoms.
Symptoms of NTM lung disease can be classified into two categories: symptoms that mainly affect the lungs and symptoms that affect the whole body.
The most common respiratory symptoms of NTM lung disease are:
•   Cough that won't go away
•   Coughing up blood (hemoptysis)
•   Shortness of breath when active
Other symptoms of NTM lung disease include:
•   Fatigue
•   Low-grade fever
•   Night sweats
•   Weight loss
What Causes NTM Lung Infections?
NTM lung infections are caused by mycobacteria that are found in the soil and water. Most people who are exposed to environmental NTM do not become sick. Doctors do not know why only some people develop NTM lung disease. In most cases, people who get sick from NTM have some other health condition like another lung disease or a weak immune system.
What Are Risk Factors for NTM Lung Disease?
•   Age: NTM lung disease is more common in older people.
•   Lung disease: Many people with NTM lung disease have another underlying lung problem like COPD, bronchiectasis, or lung damage due to previous infections such as tuberculosis.
•   Slender Caucasian women: Some women appear to have an increased risk of developing NTM disease. These women share physical features like being tall and slender, having a curved spine, abnormalities of the breastbone, and mitral valve prolapse.
•   Weak immune system: Illnesses that affect the immune system, like Sjogren’s disease and rheumatoid arthritis, may increase the risk of NTM infection. Also, certain drugs that can weaken the immune system, such as prednisone and other steroids, can increase the risk of NTM infection.
•   Esophageal disorders: Acid reflux (GERD) and other disorders of the esophagus can increase the risk of NTM lung disease due to spillage of gastric contents into the lung.
•   Environment: Exposure to NTM in our environment can result in infection. High-risk sources include indoor hot tubs and pools and exposure to soil.
When to See Your Doctor
If you have a persistent cough, particularly if you also have fatigue, night sweats, shortness of breath or weight loss, you should see your doctor immediately. If your primary care provider cannot help your chronic cough, you might need to see a lung specialist.
Diagnosing and Treating NTM Pulmonary Disease
Diagnosis of NTM lung disease is often delayed because the symptoms are similar to other lung diseases like bronchiectasis, COPD or bronchitis. However, once NTM infection is suspected, diagnosis is not difficult. When a specimen is sent to the lab, it can easily be identified whether or not the person has NTM and what species is causing the disease. This will influence the type of treatment you receive.
What to Expect
If you are diagnosed with NTM pulmonary disease, you may never have symptoms or have them only after many years. However, once symptoms develop, it may be difficult to completely relieve all symptoms with treatment. Therefore, early diagnosis and treatment are essential for good outcomes.
How It's Diagnosed
A typical diagnostic evaluation by your healthcare provider will include:

•   Detailed medical history
•   Physical examination
•   Pulmonary function tests
•   Chest X-ray
•   Computed tomography (CT) scan
•   Sputum culture
A chest X-ray may provide the first hint that NTM are present. However, a CT scan is often required to show more detail that can help confirm NTM. The CT scan can show the presence of small nodules (sometimes referred to as "tree-in-bud" because of their branch like appearance). The CT scan can also identify cavities or holes in the lung, which represent a more destructive form of infection.
A definitive diagnosis of NTM infection is through culture of a respiratory specimen, usually mucus you cough up (sputum). In some cases, where sputum cannot be not produced, a bronchoscopy is performed to obtain the specimen.

How It's Treated
NTM are relatively resistant to antibiotics and can become more resistant if only one antibiotic is used to treat the infection. Effective treatment requires two to three drugs: the exact drug and combination of drugs depending on the NTM species involved, how bad the infection is, and results of drug susceptibility testing. Treatment should continue until the respiratory culture results have been negative for at least 12 months.
•   Treatment of MAC and M kansasii, the most common causes of pulmonary NTM disease, requires three drugs given either 3 days a week or daily, depending on the severity of disease.
•   Treatment of M abscessus is more complicated and associated with poorer treatment outcomes compared with MAC and M kansasii. Patients require several months of treatment with one to two intravenous (IV) drugs in combination with oral and sometimes inhaled antibiotics.
Some patients will need surgery to remove the most damaged areas of the lung. However, this should only be considered after consultation with experts in NTM and surgery. In most cases, surgery can be performed using VATS (video-assisted thoracoscopic surgery).
Side effects of drug treatment are common, but most people can complete treatment as prescribed. You may need to get your blood tested regularly to make sure you are taking the right levels of drugs and to make sure your body is handling the drugs well. You may also need to have a vision and hearing test before and during treatment to make sure the drugs are not affecting your sight or hearing.
“unlike TB, which is spread from person to person, NTM is not contagious.”

https://www.lung.org/lung-health-and-diseases/lung-disease-lookup/nontuberculosis-mycobacteria/questions-ask-doctor-ntm.html
Questions to Ask Your Doctor About NTM Pulmonary Disease
Making notes before your visit, as well as taking along a trusted family member or friend, can help you through the first appointment with your doctor.
•   Which strain of NTM do I have?
•   What will happen if I am not treated for the infection?
•   If treated, what drugs will I take and for how long?
•   What are the potential side effects of treatment? How will you monitor me?
•   Should I have surgery to remove the infected part of my lung?
•   What is my chance of cure?
•   Can I get infected again? If so, how can I prevent getting infected again?
•   Am I contagious?
•   Besides taking antibiotics, what other treatments can I take to improve my symptoms?
NTM Lung Disease Treatment
•   Amikacin. Amikacin is from a class of medications called aminoglycosides. ...
•   Rifampin. Rifampin is taken orally in pill form. ...
•   Ethambutol. Ethambutol is a pill administered according to the patient's weight in kilograms. ...
•   Azithromycin. ...
•   Clarithromycin. ...
•   Streptomycin. ...
•   Clofazimine. 

NOTE: Antibiotics, these are not ones for NTM, these are for contagious diseases which NTM is not,
Doxyxycline and Cefdinir  cephalosporin
Cefdinir (Omnicef) is an oral third-generation cephalosporin with good in vitro activity against many pathogens commonly causative in community-acquired infections.
•   

https://www.sciencedirect.com/science/article/pii/S135964461830045X#bbib0070
NTM drug discovery: status, gaps and the way forward
Mycobacterium kansasiiand Mycobacterium xenopi. In general, macrolide-based (clarithromycin or azithromycin) multidrug regimens are prescribed.
Highlights
o   Incidence of lung disease caused by non-TB mycobacteria (NTM) is increasing.
o   Current treatments are ineffective.
o   •There is an urgent need to establish a drug pipeline.
o   •Intrinsic bacterial resistance and persistence present major challenges.
   •Predictive persister assays and animal models need to be developed.
Incidence of pulmonary diseases caused by non-tuberculous mycobacteria (NTM), relatives of Mycobacterium tuberculosis, is increasing at an alarming rate, surpassing tuberculosis in many countries. Current chemotherapies require long treatment times and the clinical outcomes are often disappointing.

https://www.webmd.com/lung/ntm-lung-disease#1
Is NTM lung disease fatal?

A more severe form is called cavitary NTM lung disease. ... This could lead to lung failure. But NTM lung disease isn't usually fatal. It's less common, but NTM infections can also show up in your skin, bones, lymph nodes, or all over your body.Jun 2, 2017
You also may be at higher risk for NTM lung disease if you’re:
•   A smoker or former smoker
•   Older
•   Female
•   Slender
•   White

NTM germs lurk in warm, wet places like hot tubs, heated indoor pools, and steamy bathrooms. If you’re at risk for the disease, it’s wise to avoid hot tubs or indoor pools. Use a vent fan to clear up steam after a shower or bath.

What Are the Symptoms?
They’re different for each person. Some people may have mild symptoms, while others have severe problems:
•   Cough, sometimes with blood
•   Fatigue
•   Fever
•   Large amount of mucus
•   Loss of appetite or weight
•   Night sweats
•   Shortness of breath
Other symptoms include wheezing, chest pain, and repeat lung infections. Over time, your lungs don’t work as well as they once did.
CONTINUE READING BELOW
NTM lung disease comes in two main types. The less severe kind is called nodular bronchiectasis. It causes scarring in your airways. That makes it hard for you to cough up and clear out mucus. Older women are most at risk for this type.
A more severe form is called cavitary NTM lung disease. In addition to scars, cavities or pits also form in your lungs. This could lead to lung failure. But NTM lung disease isn’t usually fatal.
It’s less common, but NTM infections can also show up in your skin, bones, lymph nodes, or all over your body.
A lung doctor (they are called pulmonologists) can figure out if you have NTM lung disease and help you get treatment.
WebMD Medical Reference Reviewed by Neha Pathak, MD on June 02, 2017




Yowbarb

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Re: MYCOBACTERIAL INFECTIONS
« Reply #2 on: May 13, 2019, 03:53:11 AM »
PLS Note: mycobacteria and mycoplasma are not the same

Yowbarb

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Re: MYCOBACTERIAL INFECTIONS
« Reply #3 on: May 13, 2019, 11:46:15 PM »
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937910/ Nontuberculous mycobacterial pulmonary disease mimicking lung cancer
Clinicoradiologic features and diagnostic implications

Yowbarb

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Re: MYCOBACTERIAL INFECTIONS
« Reply #4 on: October 29, 2019, 06:27:52 PM »

ilinda

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Re: MYCOBACTERIAL INFECTIONS
« Reply #5 on: October 30, 2019, 10:10:31 AM »
Copying here some notes, quickly put together about two weeks ago:
.....
NTM Nontuberculous Mycobacteria
Thanks for posting this, as I had only thought about two, and only two, forms of mycobacteria:  TB and Leprosy, but as it turns out from this and other of your posts, there are quite a few Mycobacteria, and not all are benign.

ilinda

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Re: MYCOBACTERIAL INFECTIONS
« Reply #6 on: October 30, 2019, 10:15:27 AM »
PLS Note: mycobacteria and mycoplasma are not the same
Wikipedia has a bit about mycoplasma, but a former co-worker, head of the Microbiology department told me years ago that mycoplasma were created in the lab when researchers stripped that outer cell coat from the bacteria, rendering it much more difficult to treat, as antibiotics don't have those cell coat antigens to attack.  Who knows how many kinds of bacteria were treated as such, leaving us with a variety of mycoplasma.

I have a friend who was treated for  two years with a low-dose antibiotic in hopes it would get rid of the mycoplasma infecting her joints, causing serious arthritis.

R.R. Book

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Re: MYCOBACTERIAL INFECTIONS
« Reply #7 on: October 30, 2019, 10:53:08 AM »
Very interesting fact sheet.

Regarding the fact that NTM's are found in biofilms, it might be worth considering that all of our mucous membranes also are essentially covered with biofilms, so maybe keeping our own membranes in healthy microbial balance might be worth considering, as well as keeping their porosity reduced by healing leaky gut for example?

I wonder how mycoplasmas would respond to harmonic frequency medicine?

« Last Edit: October 30, 2019, 11:09:45 AM by R.R. Book »

ilinda

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Re: MYCOBACTERIAL INFECTIONS
« Reply #8 on: October 31, 2019, 07:01:31 PM »
Very interesting fact sheet.

Regarding the fact that NTM's are found in biofilms, it might be worth considering that all of our mucous membranes also are essentially covered with biofilms, so maybe keeping our own membranes in healthy microbial balance might be worth considering, as well as keeping their porosity reduced by healing leaky gut for example?

I wonder how mycoplasmas would respond to harmonic frequency medicine?
Betting dollars to donuts that mycoplasma would respond in the way we want, once the operator of the equipment knows or learns how to "scan" and determine the frequency(ies) to which the organism is susceptible. 

R.R. Book

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Re: MYCOBACTERIAL INFECTIONS
« Reply #9 on: November 01, 2019, 04:45:10 AM »
You're probably right - found it:

Mycoplasma Infections: 0.19, 0.40, 0.95, 2.50, 32.50, 97.50, 160.03, 532.50, 817.54, 923.01

https://altered-states.net/barry/rifefrequencies/rifemachinefrequenciesM.htm

ilinda

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Re: MYCOBACTERIAL INFECTIONS
« Reply #10 on: November 01, 2019, 10:53:55 AM »
You're probably right - found it:

Mycoplasma Infections: 0.19, 0.40, 0.95, 2.50, 32.50, 97.50, 160.03, 532.50, 817.54, 923.01

https://altered-states.net/barry/rifefrequencies/rifemachinefrequenciesM.htm
"Amazing", "incredible",  and "wonderful" are total understatements to Rife and his inventions/discoveries.  The various purchase options are so varied that it might take a day just to read and compare their features.

The ONLY problem with any of this, is what would prevent TPTB from confiscatiing and destroying modern-day machines again?  It would be no surprise if they allowed a certain number to be sold, then track the buyers down and do what they did to Rife.  That would be the biggest drawback to buying one of the units, which sound almost too good to be true.  But if they are truly based on Rife's original work, I would believe they have merit.  Thanks so much for posting.

R.R. Book

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Re: MYCOBACTERIAL INFECTIONS
« Reply #11 on: November 01, 2019, 11:55:05 AM »
Mine was built from a kit a decade ago in the garage of a natural healer who lives in the Amish country.  It might be difficult to track.  And because the vacuum tube is so delicate, I keep the unit under a stack of old quilts.  ;D

R.R. Book

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Re: MYCOBACTERIAL INFECTIONS
« Reply #12 on: November 01, 2019, 12:29:04 PM »

R.R. Book

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Re: MYCOBACTERIAL INFECTIONS
« Reply #13 on: November 01, 2019, 12:36:10 PM »

ilinda

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Re: MYCOBACTERIAL INFECTIONS
« Reply #14 on: November 02, 2019, 05:24:08 PM »
Mine was built from a kit a decade ago in the garage of a natural healer who lives in the Amish country.  It might be difficult to track.  And because the vacuum tube is so delicate, I keep the unit under a stack of old quilts.  ;D
No doubt yours is safe.

 

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