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Author Topic: ALZHEIMERS - BRAIN HEALTH posts  (Read 4918 times)

Yowbarb

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ALZHEIMERS - BRAIN HEALTH posts
« on: November 01, 2017, 09:17:47 AM »
This new Topic whill be a place for Alzheimers and brain health posts.

I just ran across a video, still watching...posting it...

https://memoryrepairprotocol.com/?aff_id=17000&subid=d0TNL4DUI1JU88C9HJJD5KDS


Yowbarb

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #1 on: November 01, 2017, 09:29:52 AM »
Yowbarb Note: Anybody here have any benefits from taking Prevagen? Memory med Prevagen.
...

https://en.wikipedia.org/wiki/Aequorin#Applications    Aequorin  (Redirected from Prevagen)
From Wikipedia, the free encyclopedia

Apoaequorin is an ingredient in "Prevagen", which is marketed by Quincy Bioscience as a memory supplement. The US Federal Trade Commission (FTC) has charged the maker of false advertising, because they claim marketing statements are not supported by scientific studies. Quincy says it will fight the charges.[38][39][40]
 

R.R. Book

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #2 on: November 01, 2017, 01:00:11 PM »
Barb, I've spent some years now perusing NIH studies on supplements for cognitive health. 
Will post a short list of the most promising supplements here, and then add study results as time permits.  I will not include botanicals (except resveratrol), just molecules that are an essential part of normal human biochemistry and may decline with age or not be ingested in large enough amounts in the diet:

Alpha lipoic acid + acetyl L carnitine combination
Carnosine
Creatine
Taurine
L-arginine
Lecithin / phosphatidyl choline
Phosphatidyl serine
B complex -100
Glutathione
NADH
Pyrroloquinoline Quinone (PQQ)
Methyl cobalamin
Vitamin C
Resveratrol
Proteolytic enzymes
Magnesium
Vitamin D3
Co-Q10
A multi-vitamin with micro-nutrients








« Last Edit: November 15, 2017, 11:29:21 AM by R.R. Book »

R.R. Book

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #3 on: November 01, 2017, 01:09:42 PM »
Here's a summary of studies on acetyl-l carnitine for cognitive support (especially in combination with alpha lipoic acid):

Acetyl-L-Carnitine is the bioavailable form of carnitine. Carnitine is a compound of the amino acids lysine + methionine. Methionine is a sulfur-based molecule, so it provides a high electrical charge. The following studies are mostly on animals, with a few notable human trials and new ones pending:

Spanish researchers concluded in 1989 that a "drastic" age-related decline in carnitine levels existed, citing a "strong reverse correlation between age and carnitine levels." Abstract here: http://www.ncbi.nlm.nih.gov/pubmed/2742580?dopt=Citation .

An American study in 2002 concluded that when acetyl carnitine is taken in conjunction with alpha lipoic acid, the master anti-oxidant glutathione is generated, improvements to mitochondria membranes yield metabolism improvements, and vitamin C (also a brain anti-oxidant) levels stored in the liver are raised to levels typical of a young person:
http://www.ncbi.nlm.nih.gov/pubmed/11854487?dopt=Citation .

Another American study in 2002 further demonstrated that the combination of the two supplements also restored damaged mitochondria, reduced genome oxidation, and improved memory performance: http://www.ncbi.nlm.nih.gov/pubmed/11854529?dopt=Citation .

A 2004 American study, in collaboration with Japan, compared regular carnitine with acetyl-L-carnitine, and found several benefits from supplementation with the acetyl-L form that did not exist with ingestion of the regular form of carnitine: http://www.juvenon.com/pdfs/489car_vs_alcar.pdf .

A 2008 American study that addressed different types of aging-related mental decline concluded that use of carnitine and other neurological supplements is safer than pharmaceuticals while matching or exceeding their benefits, and should begin at the very earliest sign of cognitive decline, well in advance of a possible diagnosis of dementia: http://www.ncbi.nlm.nih.gov/pubmed/18590347 .

A 2009 American study acknowledged the body of evidence existing to-date on benefits of carnitine supplementation in the aging, specifically upon mitochondrial functioning, and questioned by what mechanism this benefit occurred. The conclusions were that supplementation increased mitochondrial gene expression and protein synthesis: http://www.ncbi.nlm.nih.gov/pubmed/19720100 .

A 2009 study at the University of Texas found that an age-related decrease in the number of surviving neuron mitochondria and presence of damaged surviving neuron mitochondria was reversed after continuous supplementation of three-months' duration: http://www.ncbi.nlm.nih.gov/pubmed/18373733 .

A 2010 American study utilizing a coctail of known neuroprotective substances including carnitine found that cognition improved in all but those over 74 years of age. It was postulated that the reason those most advanced in age did not respond to supplementation was that they suffered from malabsorption of nutrients due to being deficient in certain micronutrients, a vicious cycle believed by the researchers to be correctable with further supplementation to bring aged subjects up to baseline: http://www.ncbi.nlm.nih.gov/pubmed/20191258 .

A 2010 American study found that dual supplementation with ALA and acetyl-L-carnitine optimizes metabolism and delays aging and diseases of aging. It further concluded that much of the population at any given time is marginally deficient in micronutrients, and that even such slight deficiencies accelerate aging at the mitochondrial level. B-vitamin therapy was another treatment modality that proved to be effective against aging-related disease: http://www.ncbi.nlm.nih.gov/pubmed/20420847 .

A 2010 Italian study and a 2012 American study concluded that carnitine is also cardio-protective, even able to regenerate cardiac mitochondria: http://www.ncbi.nlm.nih.gov/pubmed/20370498 and http://www.ncbi.nlm.nih.gov/pubmed/22322067 .

A 2010 study in humans found that supplementation improved reaction time, focus and alertness: http://www.ncbi.nlm.nih.gov/pubmed/21156078 .

A 2011 Italian study of acetyl-L-carnitine's ability to reverse aging-related damage to mitochondria associated with protein metabolism found that supplementation corrected 26 out of 31 abnormal protein levels: http://www.ncbi.nlm.nih.gov/pubmed/21672642 .

In 2012, Norwegian researchers demonstrated that regular supplementation with acetyl-L-carnitine increased energy production in the brain and supported neurotransmitter levels: http://www.ncbi.nlm.nih.gov/pubmed/22549035 .

A 2014 American study used modern radiographic imaging techniques to demonstrate that acetyl-L-carnitine is not only neuroprotective, but conserves other brain anti-oxidants under stress: http://www.ncbi.nlm.nih.gov/pubmed/25461739 .

A 2015 study of acetylcarnitine as part of a nutritional formula given to patients with Alzheimer's Disease found improvement within 3 months, and at worst found that they maintained baseline without losing further ground to the disease: https://www.ncbi.nlm.nih.gov/pubmed/25589719

A 2016 study suggested that serum levels of acetylcarnitine could be a valuable marker in distinguishing between pre-Alzheimer's Disease and actual onset, helping to identify patients who could benefit from acetylcarnitine therapy: https://www.ncbi.nlm.nih.gov/pubmed/27196316

Another 2016 study recommended inclusion of acetylcarnitine as part of a nutritional coctail used to prevent further decline in patients already suffering from early onset of AD: https://www.ncbi.nlm.nih.gov/pubmed/26967219

A 2017 study found "a high efficacy" in use of acetylcarnitine for a variety of aging-related diseases: https://www.ncbi.nlm.nih.gov/pubmed/28980618 .

Another 2017 study suggested use of acetylcarnitine as a strategy for preventing or delaying onset of diseases of cognitive decline in the aging: https://www.ncbi.nlm.nih.gov/pubmed/28807823

This general fact sheet from the NIH confirms that endogenous production of carnosine declines with age (see discussion under "aging").  It is therapeutic in high doses of more than a gram per day, and suggested for use in both mild cognitive decline and Alzheimer's Disease.
https://ods.od.nih.gov/factsheets/Carnitine-HealthProfessional/

The University of Maryland Medical Center suggests supplementation with 1-3 grams per day of acetyl-L-carnitine here: http://umm.edu/health/medical/altmed/supplement/carnitine-lcarnitine . The Linus Pauling Institute of Oregon State University recommends 500-1,000 mg instead: http://lpi.oregonstate.edu/infocenter/othernuts/carnitine/ , and says that an additional benefit of supplementing with the acetyl-L-carnitine form is that extra acetyl groups become bioavailable for the production of the neurotransmitter acetylcholine. The website further says that toxic effects have not been reported.

I have edited the Wikipedia page on this topic tonight to bring it up to date, as the most recent citations there were for studies from 2003 and prior.  We'll see if an editorial battle ensues, or if an editorial robot automatically reverts my changes (both can happen). 


« Last Edit: November 02, 2017, 02:33:48 PM by R.R. Book »

R.R. Book

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #4 on: November 01, 2017, 01:32:18 PM »
Here's a summary of studies on taurine for cognitive support:

Taurine is a compound of the amino acids methionine and cysteine, but is not used by the body to build proteins the way other amino acid molecules are used. Instead, it is used by the body in large quantities for numerous other purposes. It is especially concentrated in central nervous system and cardiac tissues, as well as muscle and retinal tissue.

In 1987, a group of American researchers first proposed that taurine functioned as a neurotransmitter in its own right. Their findings were published in 2003: http://www.sciencedirect.com/science/article/pii/0165017387900129 .

In 1991, Chilean researchers concluded that although younger humans were known to be able to synthesize their own taurine endogenously, aging humans had increasingly less ability to do so. Abstract here: http://www.ncbi.nlm.nih.gov/pubmed/1811446 .

A detailed 63-page 1992 description of taurine's functions in the human body is here: http://physrev.physiology.org/content/72/1/101.full-text.pdf+html . Some of the highlights of that primer include:

* the high electro-conductivity of taurine due to its sulfur content (p.4)
* its presence in the animal kingdom, but not in plants
* the odd fact that taurine is used in large quantities in the human body but excreted unchanged by any of the reactions (p.7)
* by the time humans are able to synthesize taurine endogenously through oxidation, the amino is already well on its way to being excreted. Therefore, the body must grab what it can of taurine waste on its way out of the system, and attempt to make the best possible use of it while it still can.
* evolutionary specialization is causing carnivores to lose their ability to synthesize taurine on their own, forcing them to consume it increasingly in meat.
* Though taurine's electricity does not directly translate into ATP, it is used indirectly to activate ATP pumps (p. 19), keeping neurons and other cells alive
* Taurine behaves as a neurotransmitter of a different type than previously named (p. 23)
* Taurine is able to influence inhibitory muscle control without directly binding to those neuron sites (p.29), (possibly preventing tremors)

As far back as 1970, notation in the Italian medical literature can be found for the use of taurine as a nutritional supplement for those suffering from Alzheimer's Disease: https://www.ncbi.nlm.nih.gov/pubmed/5421986

In 1999, American researchers concluded that a correlation existed between reduction of dopamine (as with Parkinson's Disease) and reduction of taurine: http://www.sciencedirect.com/science/article/pii/S0361923099000039 .

In 2001, Venezuelan researchers concluded that taurine is necessary both for initial formation of the human central nervous system, and for its regeneration later in life: http://www.ncbi.nlm.nih.gov/pubmed/11843263 . They conclude that taurine is an essential, rather than either a non-essential or conditionally essential, amino acid. A more recent American study along similar lines from 2008 is here: http://www.sciencedirect.com/science/article/pii/S0079612308606937 .

A 2004 study demonstrated that high concentrations of taurine protect the brain from damaging beta-amyloid peptides by blocking glutamate receptors (i.e. blocking excitotoxins):
https://www.ncbi.nlm.nih.gov/pubmed/15003996

In 2007, taurine was listed as an experimental therapy for Alzheimer's Disease: https://www.ncbi.nlm.nih.gov/pubmed/17539055

In 2009, American researchers concluded that taurine mitigates side effects of brain plaques (p. 3) (excitotoxicity, oxidative stress, mitochondrial dysfunction, cell death): abstract here: http://www.ncbi.nlm.nih.gov/pubmed/19239147 , paraphrased in this longer article here: http://download.springer.com/static/pdf/610/art%253A10.1007%252Fs00726-013-1632-8.pdf?auth66=1423524204_dbd35000c5f4a08ddab0352e48efa9df&ext=.pdf .

A 2013 study of cerebro-spinal fluid in patients with Alzheimer's found a correlation between the presence of taurine and absence of depression and behavioral disturbances associated with AD (in other words, taurine may have lessened the severity of the disease): https://www.ncbi.nlm.nih.gov/pubmed/23159046

2013 research, published in 2014, confirmed neuroprotectivity of taurine, as well as an effect on functioning of neurotransmitters, in addition to anti-oxidant / anti-inflammatory functions: http://download.springer.com/static/pdf/610/art%253A10.1007%252Fs00726-013-1632-8.pdf?auth66=1423524204_dbd35000c5f4a08ddab0352e48efa9df&ext=.pdf . The study further proposed specific mitigation of taurine upon Parkinson's Disease, via inhibiting the excitatory response causing tremors, and the accompanying neuron cell death caused by the excitotoxicity.

Another 2013 study concluded that taurine supplementation produces effects that are in direct opposition to aging related cognitive dysfunction: http://link.springer.com/article/10.1007%2Fs00726-013-1544-7 .

A 2014 study describes how Alzheimer's Disease and adult-onset diabetes are essentially one and the same disease, noting that the brain responds to a severe drop in blood sugar by releasing a whole cluster of excitotoxins, followed by a flood of taurine - to the extent that it is available - to protect the brain from injury from the excitotoxins: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086025/

A 2017 study recommended 1000 mg daily to reverse cognitive deficits caused by Alzheimer's Disease by binding directly to beta-amyloid placques: https://www.ncbi.nlm.nih.gov/pubmed/28849459

Another 2017 study also found that by introducing taurine as part of a supplemental carbohydrate, the taurine would bind to beta-amyloid placques and prevent them from mis-folding, and thus from obstructing neurons and causing their death: https://www.ncbi.nlm.nih.gov/pubmed/28849458

A patented supplement called Taurizine (taurine + zinc), which has existed since at least 1985, was developed for the prevention of aging-related dementia: https://chem.nlm.nih.gov/chemidplus/rn/130007-55-5

and: http://www.reference.md/files/C048/mC048332.html


« Last Edit: November 02, 2017, 11:50:05 AM by R.R. Book »

ilinda

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #5 on: November 01, 2017, 06:42:05 PM »
This new Topic whill be a place for Alzheimers and brain health posts.

I just ran across a video, still watching...posting it...

https://memoryrepairprotocol.com/?aff_id=17000&subid=d0TNL4DUI1JU88C9HJJD5KDS
Thanks for starting this, Barb.  It is a much-needed topic.  As soon as I dig out my notes from the multi-part series on Alzheimer's Disease, I'll post a few things here as well.  A lot of what is in the video you linked, is/was also discussed in the series I watched, narrated by Peggy Sarlen (sp). 

And especially important is the narrator's commentary on how BigPharma doesn't want anyone to know the truth--that their drugs do little or nothing, while there are many natural foods, herbs and spices that have the capacity to help reverse dementia of several types.

R.R. Book

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #6 on: November 02, 2017, 04:10:18 PM »
Notes on Carnosine:

Carnosine is a combination of beta-alanine and histidine with the potential to suppress a number of different aging-related brain changes.  Normally found in high concentrations in the brain.  Exerts anti-oxidant activity by chelating metals and scavenging free-radicals, according to PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/L-Carnosine#section=Top

A 2000 study of zinc and copper toxicity was among the earliest on record to suggest neuroprotectivity of carnosine.  https://www.ncbi.nlm.nih.gov/pubmed/10661495

Another 2000 study refers to carnosine as "a natural anti-senescence drug" capable of extending the lifespan of cells in vitro.  https://www.ncbi.nlm.nih.gov/pubmed/10951108

A 2001 study lists numerous benefits of carnosine, echoed in other studies below.  It delays aging and rejuvenates cells by:
1. anti-oxidation
2. heavy metal scavenging
3. free-radical scavenging
4. neutralizes toxins
5. suppresses diabetic rise in blood pressure
6. prevents sugars from attaching to proteins
https://www.ncbi.nlm.nih.gov/pubmed/11470131

A 2005 study extolled the benefits of a carnivorous diet, partly for its carnosine content.  https://www.ncbi.nlm.nih.gov/pubmed/15955546

A 2009 study postulates a link between Alzheimer's Disease and type 2 diabetes, saying that there exists no pharmaceutical solution to the problem and that supplementation is needed to address a broad range of needs:
1. anti-inflammation
2. anti-oxidant able to chelate metals
3. prevention of sugars binding to proteins
The study suggests that carnosine might answer all of those needs, and additionally is able to neutralize a high-fructose diet.  Furthermore it both prevents aging of cells and is capable of rejuvenating aged cells.  Acetylcarnosine is more likely to survive biodegradation intact and be useful than plain carnosine.  In spite of carnosine's many known benefits, including virtual non-toxicity, the study concludes that clinical trials will remain sparse due to the pharmaceutical industry's lack of ability to patent and profit from it.  Thus experimentation with it will need to be made independently.  https://www.ncbi.nlm.nih.gov/pubmed/19402768
and http://www.tandfonline.com/doi/full/10.1586/ern.09.32?scroll=top&needAccess=true

A 2010 study stated plainly that protection of the mitochondria helps to prevent aging by maintaining regular production of Nicotinamide Adenine Dinucleotide (NAD+), a derivitive of vitamin B-3 which:
1.  prevents the genesis of altered proteins that can cause neurological damage,
2. makes efficient use of glucose, and
3. increases production of the master anti-oxidant glutathione. 
Carnosine protects the mitochondria by
1. suppressing toxins,
2. supporting creation of healthy proteins that are protective against stress, and
3. decreasing telomere shortening. 
The study regards carnosine as non-toxic.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874395/

A 2010 study lists, among other benefits of carnosine, stimulation of micro-circulation in the brain as well as pH buffering.  The study concludes that carnosine is highly effective in geriatric medicine with no side effects.  https://www.ncbi.nlm.nih.gov/pubmed/20017611

A 2011 study lists these benefits of carnosine:
1. anti-oxidation
2. prevents sugars from sticking to proteins
3. chelation
4. wound healing
5. free-radical scavenging
6. effective in treatment of both brain damage and brain degeneration
7. catalyzes beneficial biochemical processes
https://www.ncbi.nlm.nih.gov/pubmed/22020110

A 2013 study concluded that carnosine has a double benefit in the aged: it eliminates aberrant proteins, and it regulates their correct structure and use in the body: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602167/

The Wikipedia article on Carnosine was updated tonight to include more study citations.

 

« Last Edit: November 02, 2017, 05:40:01 PM by R.R. Book »

Yowbarb

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #7 on: November 02, 2017, 04:47:24 PM »
This new Topic whill be a place for Alzheimers and brain health posts.

I just ran across a video, still watching...posting it...

https://memoryrepairprotocol.com/?aff_id=17000&subid=d0TNL4DUI1JU88C9HJJD5KDS
Thanks for starting this, Barb.  It is a much-needed topic.  As soon as I dig out my notes from the multi-part series on Alzheimer's Disease, I'll post a few things here as well.  A lot of what is in the video you linked, is/was also discussed in the series I watched, narrated by Peggy Sarlen (sp). 

And especially important is the narrator's commentary on how BigPharma doesn't want anyone to know the truth--that their drugs do little or nothing, while there are many natural foods, herbs and spices that have the capacity to help reverse dementia of several types.

ilinda your post is very heartening! I love the thought that natures phamacy can reverse so many brain diseases!
:)
Oh I see the name is there, Oh! Maybe this is the one you had referred to? Found this one:   


Peggy Sarlin Interview - Awakening From Alzheimer's

https://youtu.be/tNXxSw6dMZQ

Sep 18, 2017 - Uploaded by WOCA The Source Radio
Peggy Sarlin Interview - Awakening From Alzheimer's - Captured Live on Ustream at http://www.ustream.tv/channel/american-radio 

Yowbarb

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #8 on: November 02, 2017, 04:54:28 PM »
RR: Referring back to your wonderful post, Reply #6 about Carnosine.
Pretty new subject to me, I think!



ilinda

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #9 on: November 02, 2017, 05:21:10 PM »
This new Topic whill be a place for Alzheimers and brain health posts.

I just ran across a video, still watching...posting it...

https://memoryrepairprotocol.com/?aff_id=17000&subid=d0TNL4DUI1JU88C9HJJD5KDS
Thanks for starting this, Barb.  It is a much-needed topic.  As soon as I dig out my notes from the multi-part series on Alzheimer's Disease, I'll post a few things here as well.  A lot of what is in the video you linked, is/was also discussed in the series I watched, narrated by Peggy Sarlen (sp). 

And especially important is the narrator's commentary on how BigPharma doesn't want anyone to know the truth--that their drugs do little or nothing, while there are many natural foods, herbs and spices that have the capacity to help reverse dementia of several types.

ilinda your post is very heartening! I love the thought that natures phamacy can reverse so many brain diseases!
:)
Oh I see the name is there, Oh! Maybe this is the one you had referred to? Found this one:   


Peggy Sarlin Interview - Awakening From Alzheimer's

https://youtu.be/tNXxSw6dMZQ

Sep 18, 2017 - Uploaded by WOCA The Source Radio
Peggy Sarlin Interview - Awakening From Alzheimer's - Captured Live on Ustream at http://www.ustream.tv/channel/american-radio
I hadn't seen that interview with her, but she had recently revised her book, second edition I think, and she narrated a nine-part or seven-part series on Alzheimer's Disease, which was sponsored by (trying to recall whether greenmedinfo.com, or thetruthabout cancer, or ??).

I took copious notes for the episodes I watched, missing only one or two.  Will find those notes asap. and post some here.

R.R. Book

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #10 on: November 02, 2017, 05:29:16 PM »
I'll be really excited to read your notes Ilinda! :)

Barb, I don't think many people are familiar with carnosine, as it probably would get confused with carnitine.  Even the NIH / NCBI database sometimes confuses the two when a search is done!

R.R. Book

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #11 on: November 03, 2017, 10:45:48 AM »
Notes on L-arginine:

L-arginine is the biologically active form of the amino acid arginine. 

In 2008, a study concluded that L-arginine is involved in the endogenous production of nitric oxide (NO), which is necessary in order to reverse underlying metabolic causes of diabetes.  NO is able to do important tasks such as clear sugar-alcohols (polyols) out of muscle tissue, preventing diabetic ketoacidosis and removing toxic by-products of the polyols.  The study did not directly address Alzheimer's Disease, but addresses the underlying cause, as the connection between AD and diabetes had not yet been widely understood in 2008 at the time of this study.  Recall from earlier posts why Alzheimer's Disease is considered now to stem from diabetes: excess sugars adhere to protein structures in the brain, causing them to become sticky and fold improperly.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709283/

In 2009, a more direct connection was made between L-arginine and Alzheimer's Disease.  The study found L-arginine to be helpful in a broad spectrum of aging-related degeneration, includine "neurotransmitter dysregulation" and brain glucose metabolism.  The study notes that there are no pharmaceutical interventions that show more than a very limited effect in ameliorating AD, and no drugs target the underlying mechanism of AD (which is metabolic).  In the previously mentioned study, it was noted that L-arginine produces NO.  This 2009 study states that the combination of L-arginine and NO together can actually function as a variety of neurotransmitters.  Also involved in the vicious metabolic diabetes-AD cycle is oxidative damage and inflammation.  The study notes that NO itself briefly causes a type of stress, as it is a stimulant (some men actually have more success in taking over-the-counter NO than drugs for erectile dysfunction because of this), but that the body quickly clears it away after making use of it.  Incidentally, while we eschew dietary sources of glutamate, NO actually produces glutamate as a memory stimulant in healthy brains; AD brains lack glutamate as a stimulant.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600464/

A 2014 study in aged humans with and without AD examined metabolic profiles for arginine iin three different areas of the brain, concluding that "arginine metabolism was dramatically altered."  https://www.ncbi.nlm.nih.gov/pubmed/24746363

A 2015 investigation of AD in mice found two anomalies.  First, the exterior of central nervous system cells contained an overabundance of arginase, a catabolic enzyme that degrades arginine down into other molecules, reducing the amount of arginine available for neuroprotection.  Secondly, there was an overabundance of microglia, phagocytes which explode in population in response to injuries, suggesting one or more possibly ongoing insults had occurred to the CNS (insults can be the result of excitotoxins, substance abuse, etc.).  The conclusions of the study suggest that a therapeutic agent be identified to suppress the arginine-degrading enzyme (or perhaps a simple arginine supplement might provide sufficient extra arginine that the catabolysis of a portion of it might not matter?).  https://www.ncbi.nlm.nih.gov/pubmed/25878270

Another 2015 study of arginine safety in pigs was extrapolated by body weight to humans, and it was found that the highest dose trialed, which was 573 mg/kg body weight in humans was safe for "at least" 3 months' duration.  The study further found that significant improvements in body mass were achieved in the reduction of fat and increase of lean protein.  https://www.ncbi.nlm.nih.gov/pubmed/25655382

Another 2015 study found that, in the wake of lipopolysaccharide-induced inflammatory brain  damage, L-arginine was able both to restore spatial memory and reverse memory deficit, but was unable to restore lost flexibility to the synapse.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620614/

A 2016 study of altered arginine metabolic enzymes in AD found over-expression of two genes causing a suppression or degradation of anabolic (inferred from text) enzymes involved in the synthesis of arginine (in other words the genes were preventing endogenous arginine production).  https://www.ncbi.nlm.nih.gov/pubmed/26971935

Far more studies exist on cerebrovascular protection offered by L-arginine due to its ability to preserve the elasticity of blood vessels.



« Last Edit: November 03, 2017, 03:05:34 PM by R.R. Book »

Yowbarb

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #12 on: November 03, 2017, 01:26:33 PM »
This new Topic whill be a place for Alzheimers and brain health posts.

I just ran across a video, still watching...posting it...

https://memoryrepairprotocol.com/?aff_id=17000&subid=d0TNL4DUI1JU88C9HJJD5KDS
Thanks for starting this, Barb.  It is a much-needed topic.  As soon as I dig out my notes from the multi-part series on Alzheimer's Disease, I'll post a few things here as well.  A lot of what is in the video you linked, is/was also discussed in the series I watched, narrated by Peggy Sarlen (sp). 

And especially important is the narrator's commentary on how BigPharma doesn't want anyone to know the truth--that their drugs do little or nothing, while there are many natural foods, herbs and spices that have the capacity to help reverse dementia of several types.

ilinda your post is very heartening! I love the thought that natures phamacy can reverse so many brain diseases!
:)
Oh I see the name is there, Oh! Maybe this is the one you had referred to? Found this one:   


Peggy Sarlin Interview - Awakening From Alzheimer's

https://youtu.be/tNXxSw6dMZQ

Sep 18, 2017 - Uploaded by WOCA The Source Radio
Peggy Sarlin Interview - Awakening From Alzheimer's - Captured Live on Ustream at http://www.ustream.tv/channel/american-radio
I hadn't seen that interview with her, but she had recently revised her book, second edition I think, and she narrated a nine-part or seven-part series on Alzheimer's Disease, which was sponsored by (trying to recall whether greenmedinfo.com, or thetruthabout cancer, or ??).

I took copious notes for the episodes I watched, missing only one or two.  Will find those notes asap. and post some here.

OK as soon as you post the newer video I will delete my other post... since it refers to an older video...
I can help locate the newer video if you like...

Yowbarb

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #13 on: November 03, 2017, 02:21:36 PM »
Barb, I've spent some years now perusing NIH studies on supplements for cognitive health. 
Will post a short list of the most promising supplements here, and then add study results as time permits.  I will not include botanicals, just molecules that are an essential part of normal human biochemistry and may decline with age or not be ingested in large enough amounts in the diet:

Alpha lipoic acid + acetyl L carnitine combination
Carnosine
Creatine
Taurine
L-arginine
Lecithin / phosphatidyl choline
Phosphatidyl serine
B complex -100
Glutathione
NADH
Pyrroloquinoline Quinone (PQQ)
Methyl cobalamin
Vitamin C
Resveratrol
Proteolytic enzymes
Magnesium
Vitamin D3
Co-Q10
A multi-vitamin with micro-nutrients

RR - I didn't acknowledge your posts...really good info... Going to write some reminders about foods for me old brain. :) Currently working on this month's Battleplan-Journal format. May add some of this info U and ilinda are posting.
Foods, health programs...I tend to keep a list within my formats.
« Last Edit: November 03, 2017, 02:35:03 PM by Yowbarb »

Yowbarb

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Re: ALZHEIMERS - BRAIN HEALTH posts
« Reply #14 on: November 03, 2017, 02:34:15 PM »
I do consume a few things on that list:
•   the CO Q10 (coenzyme Q10, 300 mg per day.) Have taken CoQ10 on and off since 1988.
•   B complex -100;
•   Carnosine (just whatever I may get from my diet mainstay - Atlantic wild-caught salmon
•   and a small amt of poultry during the  month.)
•   Vitamin C complex

 

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